日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Asciminib in combination with imatinib, nilotinib, or dasatinib in patients with chronic myeloid leukemia in chronic or accelerated phase: phase 1 study final results

Asciminib联合伊马替尼、尼洛替尼或达沙替尼治疗慢性期或加速期慢性粒细胞白血病患者:1期研究最终结果

Cortes, Jorge E; Lang, Fabian; Rea, Delphine; Hochhaus, Andreas; Breccia, Massimo; Goh, Yeow Tee; Heinrich, Michael C; Hughes, Timothy P; Janssen, Jeroen J W M; le Coutre, Philipp; Minami, Hironobu; Sasaki, Koji; DeAngelo, Daniel J; Sanchez-Olle, Gessami; Pognan, Nathalie; Cao, Meng; Hoch, Matthias; Mauro, Michael J

Asciminib monotherapy in patients with chronic myeloid leukemia in chronic phase without BCR::ABL1(T315I) treated with at least 2 prior TKIs: Phase 1 final results

Asciminib单药治疗既往接受过至少2种TKI治疗的慢性期慢性粒细胞白血病(无BCR::ABL1(T315I)突变)患者:I期临床试验最终结果

Hochhaus, Andreas; Kim, Dong-Wook; Cortes, Jorge E; Sasaki, Koji; Mauro, Michael J; Hughes, Timothy P; Breccia, Massimo; Talpaz, Moshe; Minami, Hironobu; Goh, Yeow Tee; DeAngelo, Daniel J; Lang, Fabian; Ottmann, Oliver; Heinrich, Michael C; Gomez Garcia de Soria, Valle; le Coutre, Philipp; Sanchez-Olle, Gessami; Cao, Meng; Pognan, Nathalie; Kapoor, Shruti; Hoch, Matthias; Rea, Delphine

The evolving role of investigative toxicology in the pharmaceutical industry

调查毒理学在制药行业中不断演变的角色

Pognan, Francois; Beilmann, Mario; Boonen, Harrie C M; Czich, Andreas; Dear, Gordon; Hewitt, Philip; Mow, Tomas; Oinonen, Teija; Roth, Adrian; Steger-Hartmann, Thomas; Valentin, Jean-Pierre; Van Goethem, Freddy; Weaver, Richard J; Newham, Peter

Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

将小胶质细胞样细胞整合到人诱导多能干细胞衍生的视网膜类器官中

Valeria Chichagova ,Maria Georgiou ,Madeleine Carter ,Birthe Dorgau ,Gerrit Hilgen ,Joseph Collin ,Rachel Queen ,Git Chung ,Jila Ajeian ,Marina Moya-Molina ,Stefan Kustermann ,Francois Pognan ,Philip Hewitt ,Michael Schmitt ,Evelyne Sernagor ,Lyle Armstrong ,Majlinda Lako

Evaluation of the Pharmacokinetic Drug Interaction of Capmatinib With Itraconazole and Rifampicin and Potential Impact on Renal Transporters in Healthy Subjects

卡马替尼与伊曲康唑和利福平的药代动力学药物相互作用评价及其对健康受试者肾脏转运蛋白的潜在影响

Cui, Xiaoming; Chen, Xinhui; Pognan, Nathalie; Sengupta, Tirtha; Rahmanzadeh, Gholamreza; Kornberger, Ruediger; Giovannini, Monica

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina

人类视网膜类器官为毒理学研究提供了合适的工具:使用影响视网膜的药物和化合物进行全面验证

Birthe Dorgau, Maria Georgiou, Alexander Chaudhary, Marina Moya-Molina, Joseph Collin, Rachel Queen, Gerrit Hilgen, Tracey Davey, Philip Hewitt, Michael Schmitt, Stefan Kustermann, Francois Pognan, David H Steel, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako

Liver enzyme delayed clearance in rat treated by CSF1 receptor specific antagonist Sotuletinib

CSF1受体特异性拮抗剂索妥替尼治疗大鼠肝酶清除延迟

François Pognan, Chiara Buono, Philippe Couttet, Jean-René Galarneau, Yoav Timsit, Armin Wolf

The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

eTRANSAFE项目:通过整合知识管理进行转化安全性评估——成就与展望

Pognan, François; Steger-Hartmann, Thomas; Díaz, Carlos; Blomberg, Niklas; Bringezu, Frank; Briggs, Katharine; Callegaro, Giulia; Capella-Gutierrez, Salvador; Centeno, Emilio; Corvi, Javier; Drew, Philip; Drewe, William C; Fernández, José M; Furlong, Laura I; Guney, Emre; Kors, Jan A; Mayer, Miguel Angel; Pastor, Manuel; Piñero, Janet; Ramírez-Anguita, Juan Manuel; Ronzano, Francesco; Rowell, Philip; Saüch-Pitarch, Josep; Valencia, Alfonso; van de Water, Bob; van der Lei, Johan; van Mulligen, Erik; Sanz, Ferran

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

磷脂沉积症是许多用于治疗SARS-CoV-2病毒感染的药物体外抗病毒活性的共同机制。

Tummino, Tia A; Rezelj, Veronica V; Fischer, Benoit; Fischer, Audrey; O'Meara, Matthew J; Monel, Blandine; Vallet, Thomas; Zhang, Ziyang; Alon, Assaf; O'Donnell, Henry R; Lyu, Jiankun; Schadt, Heiko; White, Kris M; Krogan, Nevan J; Urban, Laszlo; Shokat, Kevan M; Kruse, Andrew C; García-Sastre, Adolfo; Schwartz, Olivier; Moretti, Francesca; Vignuzzi, Marco; Pognan, Francois; Shoichet, Brian K

Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human

小鼠长期接受 S1P 调节剂西泊芬莫德治疗后诱发血管肉瘤,且与大鼠和人类无相关性

Francois Pognan, J Andreas Mahl, Maria Papoutsi, David Ledieu, Marc Raccuglia, Diethilde Theil, Sarah B Voytek, Patrick J Devine, Katie Kubek-Luck, Natalie Claudio, Andre Cordier, Annabelle Heier, Carine Kolly, Andreas Hartmann, Salah-Dine Chibout, Page Bouchard, Christian Trendelenburg