日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells

AMPK-FOXO1-PDK4 通路的上调是 tafazzin 缺乏细胞中丙酮酸脱氢酶活性降低的主要机制

Zhuqing Liang, Tyler Ralph-Epps, Michael W Schmidtke, Pablo Lazcano, Simone W Denis, Mária Balážová, Nevton Teixeira da Rosa Jr, Mohamed Chakkour, Sanaa Hazime, Mindong Ren, Michael Schlame, Riekelt H Houtkooper, Miriam L Greenberg

Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells

AMPK-FOXO1-PDK4 通路的上调是丙酮酸脱氢酶活性降低的主要机制,并导致缺乏 tafazzin 的细胞对葡萄糖的吸收增加

Zhuqing Liang, Tyler Ralph-Epps, Michael W Schmidtke, Pablo Lazcano, Simone W Denis, Mária Balážová, Mohamed Chakkour, Sanaa Hazime, Mindong Ren, Michael Schlame, Riekelt H Houtkooper, Miriam L Greenberg

Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase

磷脂酸通过诱导激酶 IP6K1 的核转位和抑制肌醇-3-P 合酶来抑制肌醇合成

Pablo Lazcano, Michael W Schmidtke, Chisom J Onu, Miriam L Greenberg

Inositol depletion regulates phospholipid metabolism and activates stress signaling in HEK293T cells

肌醇耗竭调节 HEK293T 细胞中的磷脂代谢并激活应激信号

Mahmoud Suliman, Kendall C Case, Michael W Schmidtke, Pablo Lazcano, Chisom J Onu, Miriam L Greenberg

TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons

TNF-α 通过激活痛觉神经元中的 Cdk5 增加活性氧的产生

Rodrigo Sandoval, Pablo Lazcano, Franco Ferrari, Nicolás Pinto-Pardo, Christian González-Billault, Elías Utreras

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

细胞周期蛋白依赖性激酶 5 通过 C 末端苏氨酸 372 的磷酸化来调节 P2X2a 受体通道门控

Claudio Coddou, Rodrigo Sandoval, Patricio Castro, Pablo Lazcano, Maria José Hevia, Milos Rokic, Bradford Hall, Anita Terse, Christian Gonzalez-Billault, Ashok B Kulkarni, Stanko S Stojilkovic, Elias Utreras

Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons

肿瘤坏死因子-α的靶向过表达可增加三叉神经元中细胞周期蛋白依赖性激酶 5 的活性和 TRPV1 依赖性的 Ca2+ 内流

Pablo Rozas, Pablo Lazcano, Ricardo Piña, Andrew Cho, Anita Terse, Maria Pertusa, Rodolfo Madrid, Christian Gonzalez-Billault, Ashok B Kulkarni, Elias Utreras