文献库，生知库 | 链接生命科学的每一步

日期影响因子

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

开发取代吡啶并[3,2-d]嘧啶类化合物作为强效且选择性的二氢叶酸还原酶抑制剂，用于治疗肺孢子菌肺炎感染

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2019.06.004

Shah, Khushbu; Queener, Sherry; Cody, Vivian; Pace, Jim; Gangjee, Aleem

发表日期：2019

文献求助收藏

Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents

针对物种特异性氨基酸残基：6-取代吡咯并[2,3-d]嘧啶类化合物作为二氢叶酸还原酶抑制剂和潜在抗机会性感染药物的设计、合成及生物学评价

期刊:Bioorganic & Medicinal Chemistry

doi:10.1016/j.bmc.2018.04.032

Shah, Khushbu; Lin, Xin; Queener, Sherry F; Cody, Vivian; Pace, Jim; Gangjee, Aleem

发表日期：2018

文献求助收藏

Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase

三种吡啶并[2,3-d]嘧啶类抗叶酸药物与人及卡氏肺孢子虫二氢叶酸还原酶结合的构效关系

期刊:Acta Crystallographica Section F-Structural Biology Communications

影响因子:1.1

doi:10.1107/S2053230X15008468

Cody, Vivian; Pace, Jim; Namjoshi, Ojas A; Gangjee, Aleem

发表日期：2015

文献求助收藏

Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants

对卡氏肺孢子虫、卡氏肺孢子虫和人二氢叶酸还原酶及其活性位点变体的强效抗叶酸抑制剂进行动力学和结构分析

期刊:Antimicrobial Agents and Chemotherapy

影响因子:4.5

doi:10.1128/AAC.00172-13

Cody, Vivian; Pace, Jim; Queener, Sherry F; Adair, Ona O; Gangjee, Aleem

发表日期：2013

文献求助收藏

Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode

对人二氢叶酸还原酶与强效选择性抑制剂2,4-二氨基-6-{2'-O-(3-羧丙基)氧基二苯并[b,f]氮杂卓-5-基}甲基蝶啶形成的二元复合物的结构分析揭示了一种不寻常的结合模式

doi:10.1107/S0907444911030071

Cody, Vivian; Pace, Jim; Nowak, Jessica

发表日期：2011

文献求助收藏

Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.

设计、合成经典和非经典 2-氨基-4-氧代-5-取代-6-乙基噻吩并[2,3-d]嘧啶类化合物，并研究其作为双重胸苷酸合成酶和二氢叶酸还原酶抑制剂及潜在抗肿瘤药物的 X 射线晶体结构

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/jm900490a

Gangjee Aleem, Li Wei, Kisliuk Roy L, Cody Vivian, Pace Jim, Piraino Jennifer, Makin Jennifer

发表日期：2009

文献求助收藏

The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex

2,4-二氨基呋喃并[2,3-d]嘧啶抗叶酸的Z异构体促进人二氢叶酸还原酶三元复合物中不寻常的晶体堆积。

期刊:Acta Crystallographica Section F-Structural Biology and Crystallization Communications

影响因子:1.1

doi:10.1107/S1744309109025548

Cody, Vivian; Pace, Jim; Lin, Lu; Gangjee, Aleem

发表日期：2009

文献求助收藏