日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques

Smac 模拟物与 eCD4-Ig 联合使用可逆转恒河猴的潜伏感染,且不减少 SHIV 病毒库。

Pache, Lars; Bui, John K; Klouser, Lindsay M; Fennessey, Christine M; Noyola, Alexander C; Einhaus, Teresa; Zhu, Haiying; Stensland, Laurence; Leguizamo, Isai; Koroma, Abubakarr A; Teriete, Peter; Chang, W L William; Hyrien, Ollivier; Duggan, Natasha N; Heimann, Dominik; Pérez-Osorio, Ailyn C; Bar, Katharine J; Cosford, Nicholas Dp; Keele, Brandon F; Hartigan-O'Connor, Dennis J; Farzan, Michael; Gardner, Matthew R; Jerome, Keith R; Chanda, Sumit K; Kiem, Hans-Peter; Peterson, Christopher W

Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.

全球 siRNA 筛选确定了对 SARS-CoV-2 复制和感染后期至关重要的人类宿主因子

Yin Xin, Pu Yuan, Yuan Shuofeng, Pache Lars, Churas Christopher, Weston Stuart, Riva Laura, Simons Lacy M, Cisneros William J, Clausen Thomas, Biddle Grace, Doss-Gollin Simon, Deming Meagan, De Jesus Paul D, Kim Ha Na, Fuentes Daniel, Whitelock John M, Esko Jeffrey D, Lord Megan S, Mena Ignacio, García-Sastre Adolfo, Hultquist Judd F, Frieman Matthew B, Ideker Trey, Pratt Dexter, Martin-Sancho Laura, Chanda Sumit K

Integrative multi-omics analysis in vivo identifies influenza virus host factors.

体内整合多组学分析鉴定流感病毒宿主因子。

Shriver Leah P, Polacco Benjamin J, Eckhardt Manon, Chang Max W, Martínez-Romero Carles, Adkins-Travis Kayla, Cahalane Celina, Haas Kelsey, Stein David A, Fourati Slim, Martin-Sancho Laura, Metreveli Giorgi, Johnson Jeffrey R, Muñoz-Moreno Raquel, Newton Billy W, Kaake Robyn M, Zhou Yuan, Jimenez-Morales David, VonDollen John, Verschueren Erik, Swaney Danielle L, Nguyen Thong T, Stevenson Erica J, Stancliffe Ethan, Patti Gary J, Albrecht Randy, Moulton Hong M, Pache Lars, Sekaly Rafick P, Benner Christopher, Hultquist Judd F, Chanda Sumit K, Garcia-Sastre Adolfo, Krogan Nevan J

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

冠状病毒蛋白在蝙蝠和人类细胞中的相互作用图谱揭示了其免疫逃避和复制的分子和遗传开关

Batra, Jyoti; Rutkowska, Magdalena; Zhou, Yuan; Ye, Chengjin; Adavikolanu, Rithika; Young, Janet M; Anand, Durga; Verma, Sooraj; Gordon, Martin; Malpotra, Shivali; Cupic, Anastasija; Kehrer, Thomas; Moen, Jack M; Winters, Declan M; Rojc, Ajda; Mena, Ignacio; Aslam, Sadaf; Martinez-Romero, Carles; Conde Viñas, Isabela; Khalil, Zain; Farrugia, Keith; Banerjee, Atoshi; Tussia-Cohen, Dafna; Santos, Melanie Dos; Maji, Sourobh; Muralidharan, Monita; Foussard, Helene; Chen, Irene P; Fuchs, Rotem; Felipe, Cj San; Zuliani-Alvarez, Lorena; Choudhury, Promisree; Obernier, Kirsten; Gracias, Ségolène; Suryawanshi, Rahul; Ibáñez, Carlos; Juste, Javier; Pache, Lars; Taha, Taha Y; Jouvenet, Nolwenn; Verba, Kliment A; Fraser, James S; Demeret, Caroline; Stroud, Robert M; van Bakel, Harm; Ott, Melanie; Hagai, Tzachi; Polacco, Ben; Swaney, Danielle L; Echeverria, Ignacia; Bouhaddou, Mehdi; Eckhardt, Manon; Malik, Harmit S; Martinez-Sobrido, Luis; Miorin, Lisa; García-Sastre, Adolfo; Krogan, Nevan J

Addressing barriers in FAIR data practices for biomedical data

解决生物医学数据 FAIR 数据实践中的障碍

Hughes, Laura D; Tsueng, Ginger; DiGiovanna, Jack; Horvath, Thomas D; Rasmussen, Luke V; Savidge, Tor C; Stoeger, Thomas; Turkarslan, Serdar; Wu, Qinglong; Wu, Chunlei; Su, Andrew I; Pache, Lars

Developing a standardized but extendable framework to increase the findability of infectious disease datasets

开发标准化且可扩展的框架,以提高传染病数据集的可查找性

Tsueng, Ginger; Cano, Marco A Alvarado; Bento, José; Czech, Candice; Kang, Mengjia; Pache, Lars; Rasmussen, Luke V; Savidge, Tor C; Starren, Justin; Wu, Qinglong; Xin, Jiwen; Yeaman, Michael R; Zhou, Xinghua; Su, Andrew I; Wu, Chunlei; Brown, Liliana; Shabman, Reed S; Hughes, Laura D

Host immune responses associated with SARS-CoV-2 Omicron infection result in protection or pathology during reinfection depending on mouse genetic background

与SARS-CoV-2 Omicron感染相关的宿主免疫反应,在再次感染时会产生保护作用或病理反应,这取决于小鼠的遗传背景。

Singh, Gagandeep; Warang, Prajakta; García-Bernalt Diego, Juan; Chang, Lauren; Bykov, Yonina; Singh, Sarabjot; Pache, Lars; Cuadrado-Castano, Sara; Webb, Brett; Garcia-Sastre, Adolfo; Schotsaert, Michael

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters.

SARS-CoV-2 变种的突破性感染增强了接种 mRNA 疫苗的金丝鼠体内的交叉反应混合免疫反应

García-Bernalt Diego Juan, Singh Gagandeep, Jangra Sonia, Handrejk Kim, Laporte Manon, Chang Lauren A, El Zahed Sara S, Pache Lars, Chang Max W, Warang Prajakta, Aslam Sadaf, Mena Ignacio, Webb Brett T, Benner Christopher, García-Sastre Adolfo, Schotsaert Michael

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

BIRC2/cIAP1是HIV-1转录的负调控因子,可作为Smac模拟物的靶点,以促进病毒潜伏期的逆转。

Pache, Lars; Dutra, Miriam S; Spivak, Adam M; Marlett, John M; Murry, Jeffrey P; Hwang, Young; Maestre, Ana M; Manganaro, Lara; Vamos, Mitchell; Teriete, Peter; Martins, Laura J; König, Renate; Simon, Viviana; Bosque, Alberto; Fernandez-Sesma, Ana; Cosford, Nicholas D P; Bushman, Frederic D; Young, John A T; Planelles, Vicente; Chanda, Sumit K

Functional genomic and high-content screening for target discovery and deconvolution

功能基因组学和高内涵筛选用于靶点发现和解卷积

Heynen-Genel, Susanne; Pache, Lars; Chanda, Sumit K; Rosen, Jonathan