日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Regulatory diversity in Bacillus thuringiensis cry genes reveals flexible evolutionary strategies for in vivo toxin expression

苏云金芽孢杆菌cry基因的调控多样性揭示了体内毒素表达的灵活进化策略

期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1014017
Gómez, Isabel; Garcia-Gómez, Blanca I; do Nascimento, Nathaly A; Infante, Oscar; Cantón, Pablo Emiliano; Pacheco, Sabino; Peláez-Aguilar, Angel E; Sanchez, Jorge; Soberón, Mario; Bravo, Alejandra
信号转导
发表日期：2026
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ABC transporters knockout in Aedes aegypti induces upregulation of paralogous genes, avoiding resistance development to Bacillus thuringiensis Cry toxins

埃及伊蚊ABC转运蛋白敲除可诱导旁系同源基因上调，从而避免对苏云金芽孢杆菌Cry毒素产生抗性

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0327221
Pacheco, Sabino; Chiñas, Marcos; Gómez, Juan Ulises; Peláez-Aguilar, Ángel Enrique; do Nascimento, Nathaly Alexandre; Cantón, Pablo Emiliano; Sánchez, Jorge; López-Molina, Samira; Gómez, Isabel; Soberón, Mario; Bravo, Alejandra
发表日期：2025
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CRISPR-Cas9 knockout of membrane-bound alkaline phosphatase or cadherin does not confer resistance to Cry toxins in Aedes aegypti

利用 CRISPR-Cas9 技术敲除膜结合碱性磷酸酶或钙黏蛋白并不能使埃及伊蚊对 Cry 毒素产生抗性。

期刊:PLoS Neglected Tropical Diseases
影响因子:3.4
doi:10.1371/journal.pntd.0012256
Pacheco, Sabino; Gallegos, Adrián S; Peláez-Aguilar, Ángel E; Sánchez, Jorge; Gómez, Isabel; Soberón, Mario; Bravo, Alejandra
发表日期：2024
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Structural changes upon membrane insertion of the insecticidal pore-forming toxins produced by Bacillus thuringiensis

苏云金芽孢杆菌产生的杀虫成孔毒素插入细胞膜后引起的结构变化

期刊:Frontiers in Insect Science
影响因子:3
doi:10.3389/finsc.2023.1188891
Pacheco, Sabino; Gómez, Isabel; Peláez-Aguilar, Angel E; Verduzco-Rosas, Luis A; García-Suárez, Rosalina; do Nascimento, Nathaly A; Rivera-Nájera, Lucero Y; Cantón, Pablo Emiliano; Soberón, Mario; Bravo, Alejandra
细胞生物学
发表日期：2023
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In vivo nanoscale analysis of the dynamic synergistic interaction of Bacillus thuringiensis Cry11Aa and Cyt1Aa toxins in Aedes aegypti

埃及伊蚊体内苏云金芽孢杆菌Cry11Aa和Cyt1Aa毒素动态协同作用的体内纳米尺度分析

期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1009199
López-Molina, Samira; do Nascimento, Nathaly Alexandre; Silva-Filha, Maria Helena Neves Lobo; Guerrero, Adán; Sánchez, Jorge; Pacheco, Sabino; Gill, Sarjeet S; Soberón, Mario; Bravo, Alejandra
发表日期：2021
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Bacillus thuringiensis Cry1Ab Domain III β-16 Is Involved in Binding to Prohibitin, Which Correlates with Toxicity against Helicoverpa armigera (Lepidoptera: Noctuidae)

苏云金芽孢杆菌 Cry1Ab 结构域 III β-16 参与与 Prohibitin 的结合，这与对棉铃虫（鳞翅目：夜蛾科）的毒性相关。

期刊:Applied and Environmental Microbiology
影响因子:3.7
doi:10.1128/AEM.01930-20
Sena da Silva, Igor Henrique; Gómez, Isabel; Pacheco, Sabino; Sánchez, Jorge; Zhang, Jie; Luque Castellane, Tereza Cristina; Aparecida Desiderio, Janete; Soberón, Mario; Bravo, Alejandra; Polanczyk, Ricardo Antônio
毒理研究
发表日期：2021
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The Cyt1Aa toxin from Bacillus thuringiensis inserts into target membranes via different mechanisms in insects, red blood cells, and lipid liposomes.

苏云金芽孢杆菌的 Cyt1Aa 毒素通过不同的机制插入昆虫、红细胞和脂质体等靶细胞膜中

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.RA120.013869
Onofre Janette, Pacheco Sabino, Torres-Quintero Mary Carmen, Gill Sarjeet S, Soberon Mario, Bravo Alejandra
细胞生物学
发表日期：2020
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Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity

通过工程改造苏云金芽孢杆菌Cyt1Aa毒素的特异性，使其毒性从双翅目昆虫转变为鳞翅目昆虫。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-018-22740-9
Torres-Quintero, Mary-Carmen; Gómez, Isabel; Pacheco, Sabino; Sánchez, Jorge; Flores, Humberto; Osuna, Joel; Mendoza, Gretel; Soberón, Mario; Bravo, Alejandra
毒理研究
发表日期：2018
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Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis)

苏云金芽孢杆菌 Cry9Aa 和 Vip3Aa 毒素之间的特异性结合增强了它们对亚洲水稻螟虫（Chilo suppressalis）的毒性。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.RA118.003490
Wang, Zeyu; Fang, Longfa; Zhou, Zishan; Pacheco, Sabino; Gómez, Isabel; Song, Fuping; Soberón, Mario; Zhang, Jie; Bravo, Alejandra
毒理研究
发表日期：2018
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Spodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin

草地贪夜蛾（Spodoptera frugiperda (JE Smith)）氨肽酶N1是苏云金芽孢杆菌Cry1Ca毒素的功能性受体

期刊:Applied and Environmental Microbiology
影响因子:3.7
doi:10.1128/AEM.01089-18
Gómez, Isabel; Rodríguez-Chamorro, Daniel E; Flores-Ramírez, Gabriela; Grande, Ricardo; Zúñiga, Fernando; Portugal, Francisco J; Sánchez, Jorge; Pacheco, Sabino; Bravo, Alejandra; Soberón, Mario
信号转导
发表日期：2018
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