Pacis Alain相关文献与解析，生知库 | 链接生命科学的每一步

Liu Linshan, Massey Ellie J, Zuo Dongmei, Pacis Alain, Demirdizen Mert, Podleszanski Elizabeth, Cinkornpumin Jessica, Gu Yu, Proud Hailey, Sanguin-Gendreau Virginie, Papavasiliou Vasilios, Hossain Ishtiaque, Jiang Zhengze, Smith Harvey W, Pastor William A, Ceppi Paolo, Muller William J

肿瘤

HER2

肿瘤免疫

Activating mutations in ESR1 contribute to an immunosuppressive breast tumor microenvironment by dampening cytokine secretion.

ESR1 的激活突变会抑制细胞因子的分泌，从而导致免疫抑制性乳腺肿瘤微环境的形成。

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.199927

Gu Yu, Zuo Dongmei, Hu Qi-Xin, Sanguin-Gendreau Virginie, Pacis Alain, Guiot Marie-Christine, Chang Alexander Chih-Chieh, Taifour Tarek, Ling Chen, Lee Adrian V, Oesterreich Steffi, Muller William J

Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation.

靶向抑制休眠型乳腺癌细胞对 PIK3C3-mTORC1 信号的依赖性可抑制转移的发生

期刊:Cancer Research

影响因子:16.6

doi:10.1158/0008-5472.CAN-23-2654

Elkholi Islam E, Robert AmÃ©lie, Malouf Camille, Wu Joshua L, Kuasne Hellen, Drapela Stanislav, Macleod Graham, HÃ©bert Steven, Pacis Alain, Calderon Virginie, Kleinman Claudia L, Gomes Ana P, Alvarez James V, Aguirre-Ghiso Julio A, Park Morag, Angers StÃ©phane, CÃ´tÃ© Jean-FranÃ§ois

Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models.

Smith-Magenis 综合征人类干细胞衍生皮层神经模型中的分子和发育缺陷。

期刊:American Journal of Human Genetics

影响因子:8.1

doi:10.1016/j.ajhg.2025.07.020

Lee Yu-Ju, Chang Ya-Ting, Cho Yoobin, Kowalczyk Max, Dragoiescu Adrian, Pacis Alain, Kailasam Senthilkumar, Lefebvre FranÃ§ois, Zhang Qihuang, Gao Xiaojing, Huang Wei-Hsiang

Aging-Associated Vacuolation of Multi-Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment.

小鼠远端输卵管多纤毛细胞的衰老相关空泡化反映了独特的细胞特性和管腔微环境

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.70051

Harwalkar Keerthana, Yamanaka Nobuko, Pacis Alain S, Zhao Selina, Teng Katie, Pitman Warwick, Taskar Mitaali, Lynn Vera, Thornton Alex Frances, Ford Matthew J, Yamanaka Yojiro

Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila

Cyrene：一种新型抗衰老化合物，可延长秀丽隐杆线虫和果蝇的寿命和健康寿命

期刊:NPJ Aging

影响因子:6

doi:10.1038/s41514-025-00309-x

AlOkda, Abdelrahman; Yadav, Shweta; Pacis, Alain; Jacob-Tomas, Suleima; Parkhitko, Andrey A; Van Raamsdonk, Jeremy M

Transposable elements are associated with the variable response to influenza infection

转座因子与对流感感染的不同反应有关

期刊:Cell Genomics

影响因子:9

doi:10.1016/j.xgen.2023.100292

Chen, Xun; Pacis, Alain; Aracena, Katherine A; Gona, Saideep; Kwan, Tony; Groza, Cristian; Lin, Yen Lung; Sindeaux, Renata; Yotova, Vania; Pramatarova, Albena; Simon, Marie-Michelle; Pastinen, Tomi; Barreiro, Luis B; Bourque, Guillaume

Genome graphs detect human polymorphisms in active epigenomic state during influenza infection

基因组图谱可检测流感感染期间处于活跃表观基因组状态的人类多态性

期刊:Cell Genomics

影响因子:9

doi:10.1016/j.xgen.2023.100294

Groza, Cristian; Chen, Xun; Pacis, Alain; Simon, Marie-Michelle; Pramatarova, Albena; Aracena, Katherine A; Pastinen, Tomi; Barreiro, Luis B; Bourque, Guillaume

Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

趋化因子表达可预测T细胞炎症，并可通过免疫检查点抑制剂治疗提高实体瘤的生存率。

期刊:npj Precision Oncology

影响因子:8

doi:10.1038/s41698-023-00428-2

Romero, Joan Miguel; Titmuss, Emma; Wang, Yifan; Vafiadis, James; Pacis, Alain; Jang, Gun Ho; Zhang, Amy; Golesworthy, Bryn; Lenko, Tatiana; Williamson, Laura M; Grünwald, Barbara; O'Kane, Grainne M; Jones, Steven J M; Marra, Marco A; Wilson, Julie M; Gallinger, Steven; Laskin, Janessa; Zogopoulos, George

Identification of a γc Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21

鉴定一种γc受体拮抗剂，该拮抗剂可阻止IL15和IL21对人组织驻留细胞毒性T细胞的重编程

期刊:Gastroenterology

影响因子:25.1

doi:10.1053/j.gastro.2019.10.006

Ciszewski, Cezary; Discepolo, Valentina; Pacis, Alain; Doerr, Nick; Tastet, Olivier; Mayassi, Toufic; Maglio, Mariantonia; Basheer, Asjad; Al-Mawsawi, Laith Q; Green, Peter H R; Auricchio, Renata; Troncone, Riccardo; Waldmann, Thomas A; Azimi, Nazli; Tagaya, Yutaka; Barreiro, Luis B; Jabri, Bana

EZH2 directs HER2+ breast cancer progression through the modulation of epithelial plasticity.

EZH2 通过调节上皮可塑性来指导 HER2+ 乳腺癌的进展。

Activating mutations in ESR1 contribute to an immunosuppressive breast tumor microenvironment by dampening cytokine secretion.

ESR1 的激活突变会抑制细胞因子的分泌，从而导致免疫抑制性乳腺肿瘤微环境的形成。

Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation.

靶向抑制休眠型乳腺癌细胞对 PIK3C3-mTORC1 信号的依赖性可抑制转移的发生

Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models.

Smith-Magenis 综合征人类干细胞衍生皮层神经模型中的分子和发育缺陷。

Aging-Associated Vacuolation of Multi-Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment.

小鼠远端输卵管多纤毛细胞的衰老相关空泡化反映了独特的细胞特性和管腔微环境

Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila

Cyrene：一种新型抗衰老化合物，可延长秀丽隐杆线虫和果蝇的寿命和健康寿命

Transposable elements are associated with the variable response to influenza infection

转座因子与对流感感染的不同反应有关

Genome graphs detect human polymorphisms in active epigenomic state during influenza infection

基因组图谱可检测流感感染期间处于活跃表观基因组状态的人类多态性

Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

趋化因子表达可预测T细胞炎症，并可通过免疫检查点抑制剂治疗提高实体瘤的生存率。

Identification of a γc Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21

鉴定一种γc受体拮抗剂，该拮抗剂可阻止IL15和IL21对人组织驻留细胞毒性T细胞的重编程