日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions.

AZ14289671 是一种高选择性且能穿透血脑屏障的不可逆 TKI,靶向 EGFRExon20 插入

Swaih Aisha M, Talbot Sara, Savoca Adriana, Thorpe Hannah, Flemington Vikki, Phillips Benjamin, Colclough Nicola, McCoull William, Radeva Veronika, Hargreaves David, Packer Martin J, Felisberto-Rodrigues Catarina, Thomson Clare, Orme Jonathan P, Deane Carly, Smith Aaron, Johnström Peter, Schou Magnus, McWilliams Lisa, Davey Paul, Enget Marianne, O'Neill Daniel, Cosulich Sabina, Floc'h Nicolas

NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24

核磁共振分子置换法为BRD4和TRIM24溴结构域的结合模式提供了新的见解

Torres, Felix; Walser, Reto; Kaderli, Janina; Rossi, Emanuele; Bobby, Romel; Packer, Martin J; Sarda, Sunil; Walker, Graeme; Hitchin, James R; Milbradt, Alexander G; Orts, Julien

IMPRESSION - prediction of NMR parameters for 3-dimensional chemical structures using machine learning with near quantum chemical accuracy

IMPRESSION——利用机器学习技术,以接近量子化学精度预测三维化学结构的核磁共振参数。

Gerrard, Will; Bratholm, Lars A; Packer, Martin J; Mulholland, Adrian J; Glowacki, David R; Butts, Craig P

Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation

利用核磁共振定量分析游离配体的构象偏好及其与生物活性构象的关系

Blundell, Charles D; Packer, Martin J; Almond, Andrew