日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ramantamig (JNJ-79635322), a novel T-cell-engaging trispecific antibody targeting BCMA, GPRC5D, and CD3, in multiple myeloma models

Ramantamig (JNJ-79635322) 是一种新型的 T 细胞结合三特异性抗体,靶向 BCMA、GPRC5D 和 CD3,用于多发性骨髓瘤模型研究。

Pillarisetti, Kodandaram; Yang, Danlin; Luistro, Leopoldo; Yao, Jianhong; Smith, Melissa; Vulfson, Peter; Testa, James S; Ponticiello, Randolph; Brodeur, Scott; Heidrich, Bradley; Packman, Kathryn; Singh, Sanjaya; Attar, Ricardo; Elsayed, Yusri; Philippar, Ulrike

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias

强效、选择性menin-KMT2A抑制剂JNJ-75276617(bleximenib)在KMT2A和NPM1改变的白血病中的临床前疗效

Kwon, Min Chul; Thuring, Jan Willem; Querolle, Olivier; Dai, Xuedong; Verhulst, Tinne; Pande, Vineet; Marien, Ann; Goffin, Dries; Wenge, Daniela V; Yue, Hong; Cutler, Jevon A; Jin, Cyrus; Perner, Florian; Hogeling, Shanna M; Shaffer, Paul L; Jacobs, Frank; Vinken, Petra; Cai, Wei; Keersmaekers, Vikki; Eyassu, Filmon; Bhogal, Balpreet; Verstraeten, Karin; El Ashkar, Sara; Perry, Jennifer A; Jayaguru, Prathiba; Barreyro, Laura; Kuchnio, Anna; Darville, Nicolas; Krosky, Daniel; Urbanietz, Gregor; Verbist, Bie; Edwards, James P; Cowley, Glenn S; Kirkpatrick, Robert; Steele, Ruth; Ferrante, Lucille; Guttke, Christina; Daskalakis, Nikki; Pietsch, E Christine; Wilson, David M; Attar, Ricardo; Elsayed, Yusri; Fischer, Eric S; Schuringa, Jan Jacob; Armstrong, Scott A; Packman, Kathryn; Philippar, Ulrike

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor

OICR12694 的发现:一种新型、高效、选择性强且口服生物利用度高的 BCL6 BTB 抑制剂

Mamai, Ahmed; Chau, Anh M; Wilson, Brian J; Watson, Iain D; Joseph, Babu B; Subramanian, Pandiaraju R; Morshed, Monzur M; Morin, Justin A; Prakesch, Michael A; Lu, Tianbao; Connolly, Pete; Kuntz, Douglas A; Pomroy, Neil C; Poda, Gennady; Nguyen, Kong; Marcellus, Richard; Strathdee, Graig; Theriault, Brigitte; Subramaniam, Ratheesh; Mohammed, Mohammed; Abibi, Ayome; Chan, Manuel; Winston, Jeffrey; Kiyota, Taira; Undzys, Elijus; Aman, Ahmed; Austin, Nigel; Du Jardin, Marc; Packman, Kathryn; Phillippar, Ulrike; Attar, Riccardo; Edwards, James; O'Meara, Jeff; Uehling, David E; Al-Awar, Rima; Privé, Gilbert G; Isaac, Methvin B

Blockade of VLA4 sensitizes leukemic and myeloma tumor cells to CD3 redirection in the bone marrow microenvironment

阻断VLA4可使白血病和骨髓瘤肿瘤细胞对骨髓微环境中的CD3重定向更加敏感。

Nair-Gupta, Priyanka; Rudnick, Stephen I; Luistro, Leopoldo; Smith, Melissa; McDaid, Ronan; Li, Yingzhe; Pillarisetti, Kodandaram; Joseph, Jocelin; Heidrich, Bradley; Packman, Kathryn; Attar, Ricardo; Gaudet, François

Teclistamab is an active T cell-redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma

Teclistamab 是一种针对 B 细胞成熟抗原的活性 T 细胞重定向双特异性抗体,用于治疗多发性骨髓瘤。

Pillarisetti, Kodandaram; Powers, Gordon; Luistro, Leopoldo; Babich, Alexander; Baldwin, Eric; Li, Yingzhe; Zhang, Xiaochun; Mendonça, Mark; Majewski, Nate; Nanjunda, Rupesh; Chin, Diana; Packman, Kathryn; Elsayed, Yusri; Attar, Ricardo; Gaudet, François

Discovery of siRNA lipid nanoparticles to transfect suspension leukemia cells and provide in vivo delivery capability

发现siRNA脂质纳米颗粒可用于转染悬浮白血病细胞并提供体内递送能力

He, Wei; Bennett, Michael J; Luistro, Leopoldo; Carvajal, Daisy; Nevins, Thomas; Smith, Melissa; Tyagi, Gaurav; Cai, James; Wei, Xin; Lin, Tai-An; Heimbrook, David C; Packman, Kathryn; Boylan, John F

Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor r1530 for the treatment of solid tumors

发现一种高效、口服有效的有丝分裂/血管生成抑制剂r1530,可用于治疗实体瘤

Liu, Jin-Jun; Higgins, Brian; Ju, Grace; Kolinsky, Kenneth; Luk, Kin-Chun; Packman, Kathryn; Pizzolato, Giacomo; Ren, Yi; Thakkar, Kshitij; Tovar, Christian; Zhang, Zhuming; Wovkulich, Peter M

Mesenchymal stem cells in early entry of breast cancer into bone marrow.

间充质干细胞在乳腺癌早期侵入骨髓中的作用

Corcoran Kelly E, Trzaska Katarzyna A, Fernandes Helen, Bryan Margarette, Taborga Marcelo, Srinivas Venkatesh, Packman Kathryn, Patel Prem S, Rameshwar Pranela

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

小分子MDM2拮抗剂揭示癌症中异常的p53信号传导:对治疗的启示

Tovar, Christian; Rosinski, James; Filipovic, Zoran; Higgins, Brian; Kolinsky, Kenneth; Hilton, Holly; Zhao, Xiaolan; Vu, Binh T; Qing, Weiguo; Packman, Kathryn; Myklebost, Ola; Heimbrook, David C; Vassilev, Lyubomir T