日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Investigating the Landscape of C6-Azaindole Side Chain on the Epoxymorphinan Skeleton via the Nitrogen Walk Concept: A Strategy to Enhance Drug-Like Properties

利用氮原子行走概念研究环氧吗啡烷骨架上C6-氮杂吲哚侧链的构象:一种增强药物活性的策略

Neel, Logan; Ma, Hongguang; Reda, Ahmed; Li, Mengchu; Flammia, Rachael; Woodard, Samuel; Gillespie, James C; Selley, Dana E; Dewey, William L; Pagare, Piyusha P; Zhang, Yan

Design, Syntheses, and Pharmacological Evaluations of Core Ring Expanded Fentanyl Analogues as Potential Counteracting Agents Against Fentanyl Induced Respiratory Depression

设计、合成和药理学评价核心环扩展芬太尼类似物作为潜在的芬太尼诱导呼吸抑制拮抗剂

Silte, Abeje A; Li, Ennian; Kale, Balaji S; Neel, Logan; Upadhyay, Neha; Flammia, Rachael; Lyu, Rui; St Onge, Celsey M; Reda, Ahmed; Woodard, Samuel; Gillespie, James C; Kim, Daniel; Selley, Dana E; Dewey, William L; Pagare, Piyusha P; Zhang, Yan

The antisickling agent, 5-hydroxymethyl-2-furfural: Other potential pharmacological applications

抗镰状细胞贫血剂5-羟甲基-2-糠醛:其他潜在的药理学应用

Pagare, Piyusha P; McGinn, Mina; Ghatge, Mohini S; Shekhar, Vibha; Alhashimi, Rana T; Daniel Pierce, B; Abdulmalik, Osheiza; Zhang, Yan; Safo, Martin K

Novel PROTAC probes targeting FOSL1 degradation to eliminate head and neck squamous cell carcinoma cancer stem cells.

新型 PROTAC 探针靶向 FOSL1 降解,以消除头颈部鳞状细胞癌干细胞

Zaman Shadid U, Pagare Piyusha P, Huang Boshi, Rilee Grace, Ma Zhikun, Zhang Yan, Li Jiong

Discovery of 6α-Thiazolylcarboxamidonaltrexamine Derivative (NTZ) as a Potent and Central Nervous System Penetrant Opioid Receptor Modulator with Drug-like Properties for Potential Treatment of Opioid Use Disorder

发现 6α-噻唑基羧酰胺阿曲沙明衍生物 (NTZ) 是一种强效且能穿透中枢神经系统的阿片受体调节剂,具有类似药物的特性,有望用于治疗阿片类药物使用障碍

Huang, Boshi; Ma, Hongguang; Pagare, Piyusha P; Li, Mengchu; Mendez, Rolando E; Gillespie, James C; Poklis, Justin L; Halquist, Matthew S; Stevens, David L; Dewey, William L; Selley, Dana E; Zhang, Yan

X-ray crystallography and sickle cell disease drug discovery-a tribute to Donald Abraham

X射线晶体学与镰状细胞病药物研发——致敬唐纳德·亚伯拉罕

Donkor, Akua K; Pagare, Piyusha P; Mughram, Mohammed H Al; Safo, Martin K

Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

利用血红蛋白变构调节治疗镰状细胞病:当前进展和知识产权

Pagare, Piyusha P; Rastegar, Aref; Abdulmalik, Osheiza; Omar, Abdelsattar M; Zhang, Yan; Fleischman, Andrew; Safo, Martin K

Rational approaches for the design of various GABA modulators and their clinical progression

各种GABA调节剂的合理设计方法及其临床进展

Bhagat, Kavita; Singh, Jatinder V; Pagare, Piyusha P; Kumar, Nitish; Sharma, Anchal; Kaur, Gurinder; Kinarivala, Nihar; Gandu, Srinivasa; Singh, Harbinder; Sharma, Sahil; Bedi, Preet Mohinder S

A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond

癌症分子伴侣的化学生物学研究——HSP90及其他

Taldone, Tony; Wang, Tai; Rodina, Anna; Pillarsetty, Naga Vara Kishore; Digwal, Chander S; Sharma, Sahil; Yan, Pengrong; Joshi, Suhasini; Pagare, Piyusha P; Bolaender, Alexander; Roboz, Gail J; Guzman, Monica L; Chiosis, Gabriela

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

对香草醛衍生物进行合理修饰,以立体特异性地破坏镰状血红蛋白聚合物的形成

Deshpande, Tanvi M; Pagare, Piyusha P; Ghatge, Mohini S; Chen, Qiukan; Musayev, Faik N; Venitz, Jurgen; Zhang, Yan; Abdulmalik, Osheiza; Safo, Martin K