日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus.

选择性抑制 Na v 1.8 对恒河猴镇痛和外周 C 纤维调节的影响

Vardigan Joshua D, Pall Parul S, McDevitt Dillon S, Huang ChienJung, Clements Michelle K, Li Yuxing, Kraus Richard L, Breslin Michael J, Bungard Christopher J, Nemenov Mikhail I, Klukinov Mikhail, Burgey Chritopher S, Layton Mark E, Stachel Shawn J, Lange Henry S, Savitz Alan T, Santarelli Vincent P, Henze Darrell A, Uslaner Jason M

Humanized Na(V)1.8 rats overcome cross-species potency shifts in developing novel Na(V)1.8 inhibitors.

人源化 Na(V)1.8 大鼠克服了开发新型 Na(V)1.8 抑制剂时跨物种效力变化的问题

McDevitt Dillon S, Vardigan Joshua D, Zhou Xiaoping, Rosahl Thomas W, Zhou Heather, Price Eric A, Clements Michelle K, Li Yuxing, Varghese Nissi, Krasowska-Zoladek Alicja, Stachel Shawn J, Breslin Michael J, Burgey Christopher S, Kraus Richard L, Pall Parul S, Henze Darrell A, Santarelli Vincent P

Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose

利用转化药代动力学-药效学模型研究NaV1.7抑制剂MK-2075在人体中的有效剂量

Ballard, Jeanine E; Pall, Parul S; Vardigan, Joshua; Zhao, Fuqiang; Holahan, Marie A; Zhou, Xiaoping; Jochnowitz, Nina; Kraus, Richard L; Klein, Rebecca M; Henze, Darrell A; Houghton, Andrea K; Burgey, Christopher S; Gibson, Christopher; Struyk, Arie

Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects

对一种新型非人灵长类动物热反应性测量方法进行药理学验证,该方法可用于预测镇痛效果

Vardigan, Joshua D; Houghton, Andrea K; Lange, Henry S; Adarayan, Emily D; Pall, Parul S; Ballard, Jeanine E; Henze, Darrell A; Uslaner, Jason M

Ablation of IB4 non-peptidergic afferents in the rat facet joint prevents injury-induced pain and thalamic hyperexcitability via supraspinal glutamate transporters

大鼠小关节中IB4非肽能传入纤维的消融可通过脊髓上谷氨酸转运体预防损伤引起的疼痛和丘脑过度兴奋。

Weisshaar, Christine L; Kras, Jeffrey V; Pall, Parul S; Kartha, Sonia; Winkelstein, Beth A

Psychophysical measurements of itch and nociceptive sensations in an experimental model of allergic contact dermatitis

在过敏性接触性皮炎实验模型中,对瘙痒和伤害性感觉进行心理物理学测量

Pall, Parul S; Hurwitz, Olivia E; King, Brett A; LaMotte, Robert H

Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents

大鼠关节内注射 NGF 或关节损伤引起的疼痛需要肽能关节传入神经的参与。

Kras, Jeffrey V; Weisshaar, Christine L; Pall, Parul S; Winkelstein, Beth A