BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice
BAC转基因表达人TREM2-R47H可重塑5xFAD小鼠的淀粉样斑块,但无法重编程斑块相关的微胶质细胞反应性。
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doi:10.1101/2023.08.03.551881
Lee, C Y Daniel; De La Rocha, Amberlene J; Inouye, Kellie; Langfelder, Peter; Daggett, Anthony; Gu, Xiaofeng; Jiang, Lu-Lin; Pamonag, Zoe; Vaca, Raymond G; Richman, Jeffrey; Kawaguchi, Riki; Gao, Fuying; Xu, Huaxi; Yang, X William