日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation

神经氨酸酶 1 继发性缺乏症通过脑蛋白过度唾液酸化作用导致神经系统粘多糖贮积症的中枢神经系统病变。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI177430
Xu, TianMeng; Heon-Roberts, Rachel; Moore, Travis; Dubot, Patricia; Pan, Xuefang; Guo, Tianlin; Cairo, Christopher W; Holley, Rebecca J; Bigger, Brian; Durcan, Thomas M; Levade, Thierry; Ausseil, Jerôme; Amilhon, Bénédicte; Gorelik, Alexei; Nagar, Bhushan; Khan, Shaukat; Tomatsu, Shunji; Sturiale, Luisa; Palmigiano, Angelo; Röckle, Iris; Thiesler, Hauke; Hildebrandt, Herbert; Garozzo, Domenico; Pshezhetsky, Alexey V
神经科学
发表日期：2025
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Cathepsin B inhibition blocks amyloidogenesis in the mouse models of neurological lysosomal diseases MPS IIIC and sialidosis.

组织蛋白酶 B 抑制剂可阻断神经溶酶体疾病 MPS IIIC 和唾液酸沉积症小鼠模型中的淀粉样蛋白生成

期刊:Molecular Therapy-Methods & Clinical Development
影响因子:4.7
doi:10.1016/j.omtm.2025.101432
Viana Gustavo M, Pan Xuefang, Fan Shuxian, Xu TianMeng, Wyatt Alexandra, Pshezhetsky Alexey V
神经科学
Mouse
血管生成
发表日期：2025
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Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption

唾液酸沉积症小鼠的严重肾功能障碍揭示了神经氨酸酶1在重吸收过程中的重要作用

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.166470
Kho, Ikhui; Demina, Ekaterina P; Pan, Xuefang; Londono, Irene; Cairo, Christopher W; Sturiale, Luisa; Palmigiano, Angelo; Messina, Angela; Garozzo, Domenico; Ung, Roth-Visal; Mac-Way, Fabrice; Bonneil, Éric; Thibault, Pierre; Lemaire, Mathieu; Morales, Carlos R; Pshezhetsky, Alexey V
发表日期：2023
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Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission

IIIC型粘多糖贮积症的早期缺陷会破坏兴奋性突触传递。

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.142073
Pará, Camila; Bose, Poulomee; Bruno, Luigi; Freemantle, Erika; Taherzadeh, Mahsa; Pan, Xuefang; Han, Chanshuai; McPherson, Peter S; Lacaille, Jean-Claude; Bonneil, Éric; Thibault, Pierre; O'Leary, Claire; Bigger, Brian; Morales, Carlos Ramon; Di Cristo, Graziella; Pshezhetsky, Alexey V
神经科学
发表日期：2021
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Structural basis for substrate specificity of mammalian neuraminidases

哺乳动物神经氨酸酶底物特异性的结构基础

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0106320
Smutova, Victoria; Albohy, Amgad; Pan, Xuefang; Korchagina, Elena; Miyagi, Taeko; Bovin, Nicolai; Cairo, Christopher W; Pshezhetsky, Alexey V
发表日期：2014
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Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression

UBIAD1基因表达沉默导致人肝细胞癌细胞线粒体损伤和胆固醇沉积。

期刊:Molecular Genetics and Metabolism Reports
影响因子:1.9
doi:10.1016/j.ymgmr.2014.09.001
Morales, Carlos R; Grigoryeva, Lubov S; Pan, Xuefang; Bruno, Luigi; Hickson, Gilles; Ngo, Michael H; McMaster, Christopher R; Samuels, Mark E; Pshezhetsky, Alexey V
肿瘤
肿瘤免疫
代谢
线粒体
细胞生物学
发表日期：2014
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