日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade

CD122 选择性 IL2 复合物可降低免疫抑制、促进 Treg 脆弱性并增强肿瘤对 PD-L1 阻断的反应

Justin M Drerup #, Yilun Deng #, Sri Lakshmi Pandeswara, Álvaro S Padrón, Ryan M Reyes, Xinyue Zhang, Jenny Mendez, Aijie Liu, Curtis A Clark, Wanjiao Chen, José R Conejo-Garcia, Vincent Hurez, Harshita Gupta, Tyler J Curiel

Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGF-β from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer

在三阴性乳腺癌中,Smad3 水平升高和 Smad2 水平降低通过 TMEPAI/PMEPA1 介导 TGF-β 从生长抑制因子功能转变为生长和转移促进因子

Prajjal K Singha, Srilakshmi Pandeswara, Hui Geng, Rongpei Lan, Manjeri A Venkatachalam, Albert Dobi, Shiv Srivastava, Pothana Saikumar

Age effects of distinct immune checkpoint blockade treatments in a mouse melanoma model

小鼠黑色素瘤模型中不同免疫检查点阻断疗法的年龄效应

Padrón, Álvaro; Hurez, Vincent; Gupta, Harshita B; Clark, Curtis A; Pandeswara, Sri Lakshmi; Yuan, Bin; Svatek, Robert S; Turk, Mary Jo; Drerup, Justin M; Li, Rong; Curiel, Tyler J

Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment

雷帕霉素在淋巴瘤和癌治疗中的双相效应

Yang Liu ,Srilakshmi Pandeswara ,Vinh Dao ,Álvaro Padrón ,Justin M Drerup ,Shunhua Lao ,Aijie Liu ,Vincent Hurez ,Tyler J Curiel

Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer

肿瘤细胞内在 PD-L1 促进黑色素瘤和卵巢癌中的肿瘤起始细胞生成和功能

Harshita B Gupta, Curtis A Clark, Bin Yuan, Gangadhara Sareddy, Srilakshmi Pandeswara, Alvaro S Padron, Vincent Hurez, José Conejo-Garcia, Ratna Vadlamudi, Rong Li, Tyler J Curiel

Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells

雷帕霉素的免疫刺激作用是通过刺激抗肿瘤γδ T细胞介导的。

Dao, Vinh; Liu, Yang; Pandeswara, Srilakshmi; Svatek, Robert S; Gelfond, Jonathan A; Liu, Aijie; Hurez, Vincent; Curiel, Tyler J

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

肿瘤内在 PD-L1 信号调节卵巢癌和黑色素瘤的细胞生长、发病机制和自噬

Curtis A Clark, Harshita B Gupta, Gangadhara Sareddy, Srilakshmi Pandeswara, Shunhua Lao, Bin Yuan, Justin M Drerup, Alvaro Padron, José Conejo-Garcia, Kruthi Murthy, Yang Liu, Mary Jo Turk, Kathrin Thedieck, Vincent Hurez, Rong Li, Ratna Vadlamudi, Tyler J Curiel

Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice

在小鼠中,使用雷帕霉素进行慢性 mTOR 抑制会改变 T 细胞、B 细胞、髓系细胞和固有淋巴细胞以及肠道菌群,并延长免疫缺陷小鼠的寿命。

Hurez, Vincent; Dao, Vinh; Liu, Aijie; Pandeswara, Srilakshmi; Gelfond, Jonathan; Sun, Lishi; Bergman, Molly; Orihuela, Carlos J; Galvan, Veronica; Padrón, Álvaro; Drerup, Justin; Liu, Yang; Hasty, Paul; Sharp, Zelton Dave; Curiel, Tyler J

Prevention of carcinogen and inflammation-induced dermal cancer by oral rapamycin includes reducing genetic damage

口服雷帕霉素预防致癌物和炎症诱发的皮肤癌包括减少基因损伤。

Dao, Vinh; Pandeswara, Srilakshmi; Liu, Yang; Hurez, Vincent; Dodds, Sherry; Callaway, Danielle; Liu, Aijie; Hasty, Paul; Sharp, Zelton D; Curiel, Tyler J

TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer

TGF-β 诱导的 TMEPAI/PMEPA1 通过 R-Smad 隔离抑制经典 Smad 信号传导,并通过降低三阴性乳腺癌中的 PTEN 促进非经典 PI3K/Akt 信号传导

Prajjal K Singha, Srilakshmi Pandeswara, Hui Geng, Rongpei Lan, Manjeri A Venkatachalam, Pothana Saikumar