Multiple patient-derived glioblastoma models reveal synthetic lethality through concurrent PI3K and CDK4/6 inhibition by blocking trans-active cooperation
多个源自患者的胶质母细胞瘤模型揭示了通过同时抑制PI3K和CDK4/6阻断反式活性协同作用而导致的合成致死效应。
期刊:Neuro-Oncology
影响因子:13.4
doi:10.1093/neuonc/noaf224
Zhang, Jing; Chen, Xu; Cheng, Meng; Wang, Jingzhe; Wu, Yueyao; Xie, Han; Zhang, Chunyu; Wang, Honghao; Pang, Ying; Ji, Tongjie; Yang, Yuntong; Yang, Junyu; Xu, Siyi; Wang, Zhigang; Wang, Qi; Liu, Min; Zhong, Chunlong
