日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A PAM of the α(1A)-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer's disease mouse models without effects on blood pressure

α(1A)-肾上腺素能受体的正向变构调节剂(PAM)可改善阿尔茨海默病小鼠模型的生物标志物、长时程增强作用和认知缺陷,且不影响血压。

Papay, Robert S; Stauffer, Shaun R; Perez, Dianne M

Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity

长期刺激α1A-肾上腺素能受体可改善突触可塑性、认知功能、情绪和寿命。

Doze, Van A; Papay, Robert S; Goldenstein, Brianna L; Gupta, Manveen K; Collette, Katie M; Nelson, Brian W; Lyons, Mariaha J; Davis, Bethany A; Luger, Elizabeth J; Wood, Sarah G; Haselton, James R; Simpson, Paul C; Perez, Dianne M

alpha1-Adrenergic receptor stimulates interleukin-6 expression and secretion through both mRNA stability and transcriptional regulation: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB.

α1-肾上腺素能受体通过mRNA稳定性和转录调控刺激白细胞介素-6的表达和分泌:p38丝裂原活化蛋白激酶和核因子-κB的参与

Perez Dianne M, Papay Robert S, Shi Ting