日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From Pharmacophore to Warhead: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors

从药效团到活性位点:靶向 NAD(+) 的三唑类化合物作为基于机制的 Sirtuin 抑制剂

Friedrich, Florian; Meleshin, Marat; Papenkordt, Niklas; Gaitzsch, Lena; Prucker, Isabel; Borso, Marco; Ruprecht, Jan; Vorreiter, Christopher; Rast, Sabrina; Zhang, Lin; Schiedel, Matthias; Sippl, Wolfgang; Imhof, Axel; Jessen, Henning J; Einsle, Oliver; Schutkowski, Mike; Jung, Manfred

Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD(+) co-factor binding.

定制的 SirReal 型抑制剂通过配体稳定和破坏 NAD(+) 辅因子结合来增强 SIRT2 抑制作用

Wirawan Ricky, Frei Matthias, Heider Anna, Papenkordt Niklas, Friedrich Florian, Wein Thomas, Jung Manfred, Groll Michael, Huber Eva M, Bracher Franz

Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors.

芳香族氨基酸羟化酶是组蛋白去乙酰化酶抑制剂的脱靶靶点

Baumann Anne, Papenkordt Niklas, Robaa Dina, Szigetvari Peter D, Vogelmann Anja, Bracher Franz, Sippl Wolfgang, Jung Manfred, Haavik Jan