Papo Niv相关文献与解析，生知库 | 链接生命科学的每一步

Mapping the sclerostin-LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin.

通过绘制硬骨蛋白-LRP4结合界面，可以确定硬骨蛋白环1和环3中的关键相互作用热点

期刊:FEBS Letters

影响因子:3

doi:10.1002/1873-3468.15033

Katchkovsky Svetlana, Meiri Reut, Lacham-Hartman Shiran, Orenstein Yaron, Levaot Noam, Papo Niv

骨科研究

发表日期：2025

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In vitro inhibition of cancer angiogenesis and migration by a nanobody that targets the orphan receptor Tie1

靶向孤儿受体Tie1的纳米抗体在体外抑制癌细胞血管生成和迁移

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-022-04336-9

Meltzer, May; Eliash, Noam; Azoulay, Ziv; Hadad, Uzi; Papo, Niv

Competitive blocking of LRP4-sclerostin binding interface strongly promotes bone anabolic functions

竞争性阻断LRP4-硬骨蛋白结合界面可显著促进骨骼合成代谢功能

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-022-04127-2

Katchkovsky, Svetlana; Chatterjee, Biplab; Abramovitch-Dahan, Chen-Viki; Papo, Niv; Levaot, Noam

代谢

发表日期：2022

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Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.

生物正交聚乙二醇化延长了 N-TIMP2 的消除半衰期，同时保留了 MMP 抑制作用

期刊:Bioconjugate Chemistry

影响因子:3.9

doi:10.1021/acs.bioconjchem.2c00059

Hayun Hezi, Arkadash Valeria, Sananes Amiram, Arbely Eyal, Stepensky David, Papo Niv

信号转导

发表日期：2022

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Amyloid β structural polymorphism, associated toxicity and therapeutic strategies

淀粉样蛋白β结构多态性、相关毒性和治疗策略

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-021-03954-z

Oren, Ofek; Taube, Ran; Papo, Niv

毒理研究

发表日期：2021

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The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils

BIM蛋白的促凋亡结构域形成有毒的淀粉样蛋白原纤维

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-020-03623-7

Malishev, Ravit; Ben-Zichri, Shani; Oren, Ofek; Shauloff, Nitzan; Peretz, Tal; Taube, Ran; Papo, Niv; Jelinek, Raz

Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy

同时靶向CD44和MMP9的催化结构域和血红素结合结构域作为一种治疗策略

期刊:Biochemical Journal

影响因子:4.3

doi:10.1042/BCJ20200628

Yosef, Gal; Hayun, Hezi; Papo, Niv

Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site

观察到二价抑制剂与具有单个活性位点的酶单体之间存在亲和力

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0249616

Lacham-Hartman, Shiran; Shmidov, Yulia; Radisky, Evette S; Bitton, Ronit; Lukatsky, David B; Papo, Niv

发表日期：2021

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Quantitative mapping of binding specificity landscapes for homologous targets by using a high-throughput method

利用高通量方法对同源靶标的结合特异性分布进行定量分析

期刊:Biochemical Journal

影响因子:4.3

doi:10.1042/BCJ20200188

Aharon, Lidan; Aharoni, Shay-Lee; Radisky, Evette S; Papo, Niv

发表日期：2020

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Modifying inhibitor specificity for homologous enzymes by machine learning

利用机器学习改变同源酶的抑制剂特异性

Mapping the sclerostin-LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin.

通过绘制硬骨蛋白-LRP4结合界面，可以确定硬骨蛋白环1和环3中的关键相互作用热点

In vitro inhibition of cancer angiogenesis and migration by a nanobody that targets the orphan receptor Tie1

靶向孤儿受体Tie1的纳米抗体在体外抑制癌细胞血管生成和迁移

Competitive blocking of LRP4-sclerostin binding interface strongly promotes bone anabolic functions

竞争性阻断LRP4-硬骨蛋白结合界面可显著促进骨骼合成代谢功能

Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.

生物正交聚乙二醇化延长了 N-TIMP2 的消除半衰期，同时保留了 MMP 抑制作用

Amyloid β structural polymorphism, associated toxicity and therapeutic strategies

淀粉样蛋白β结构多态性、相关毒性和治疗策略

The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils

BIM蛋白的促凋亡结构域形成有毒的淀粉样蛋白原纤维

Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy

同时靶向CD44和MMP9的催化结构域和血红素结合结构域作为一种治疗策略

Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site

观察到二价抑制剂与具有单个活性位点的酶单体之间存在亲和力

Quantitative mapping of binding specificity landscapes for homologous targets by using a high-throughput method

利用高通量方法对同源靶标的结合特异性分布进行定量分析