日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types

循环肿瘤DNA能够灵敏地检测各种癌症类型中可靶向的基因融合和重排

Kasi, Pashtoon M; Lee, Jessica K; Pasquina, Lincoln W; Decker, Brennan; Vanden Borre, Pierre; Pavlick, Dean C; Allen, Justin M; Parachoniak, Christine; Quintanilha, Julia C F; Graf, Ryon P; Schrock, Alexa B; Oxnard, Geoffrey R; Lovly, Christine M; Tukachinsky, Hanna; Subbiah, Vivek

Tumor Fraction Correlates With Detection of Actionable Variants Across > 23,000 Circulating Tumor DNA Samples

在超过23000个循环肿瘤DNA样本中,肿瘤细胞比例与可操作变异的检测呈正相关

Husain, Hatim; Pavlick, Dean C; Fendler, Bernard J; Madison, Russell W; Decker, Brennan; Gjoerup, Ole; Parachoniak, Christine A; McLaughlin-Drubin, Molly; Erlich, Rachel L; Schrock, Alexa B; Frampton, Garrett M; Das Thakur, Meghna; Oxnard, Geoffrey R; Tukachinsky, Hanna

MET Genomic Alterations in Head and Neck Squamous Cell Carcinoma (HNSCC): Rapid Response to Crizotinib in a Patient with HNSCC with a Novel MET R1004G Mutation

MET基因组改变与头颈部鳞状细胞癌(HNSCC):携带新型MET R1004G突变的HNSCC患者对克唑替尼治疗反应迅速

Chu, Lisa Pei; Franck, Debra; Parachoniak, Christine A; Gregg, Jeffrey P; Moore, Michael G; Farwell, D Gregory; Rao, Shyam; Heilmann, Andreas M; Erlich, Rachel L; Ross, Jeffrey S; Miller, Vincent A; Ali, Siraj; Riess, Jonathan W

CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration

CLIP-170 空间调节受体酪氨酸激酶循环以协调细胞迁移

Kossay Zaoui, Stephanie Duhamel, Christine A Parachoniak, Morag Park

Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer

内分泌治疗耐药性乳腺癌中复发性高活性 ESR1 融合蛋白

Hartmaier, R J; Trabucco, S E; Priedigkeit, N; Chung, J H; Parachoniak, C A; Vanden Borre, P; Morley, S; Rosenzweig, M; Gay, L M; Goldberg, M E; Suh, J; Ali, S M; Ross, J; Leyland-Jones, B; Young, B; Williams, C; Park, B; Tsai, M; Haley, B; Peguero, J; Callahan, R D; Sachelarie, I; Cho, J; Atkinson, J M; Bahreini, A; Nagle, A M; Puhalla, S L; Watters, R J; Erdogan-Yildirim, Z; Cao, L; Oesterreich, S; Mathew, A; Lucas, P C; Davidson, N E; Brufsky, A M; Frampton, G M; Stephens, P J; Chmielecki, J; Lee, A V

Exceptional durable response to everolimus in a patient with biphenotypic breast cancer harboring an STK11 variant

一名携带 STK11 变异体的双表型乳腺癌患者对依维莫司治疗表现出卓越的持久疗效

Parachoniak, Christine A; Rankin, Andrew; Gaffney, Bernadette; Hartmaier, Ryan; Spritz, Dan; Erlich, Rachel L; Miller, Vincent A; Morosini, Deborah; Stephens, Phil; Ross, Jeffrey S; Keech, John Jr; Chmielecki, Juliann

Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3

内体衔接子 GGA3 对细胞迁移和 β1 整合素运输的调节

Colin D H Ratcliffe, Pranshu Sahgal, Christine A Parachoniak, Johanna Ivaska, Morag Park

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

YAP抑制剂可恢复晚期肝细胞癌中的肝细胞分化,从而导致肿瘤消退

Fitamant, Julien; Kottakis, Filippos; Benhamouche, Samira; Tian, Helen S; Chuvin, Nicolas; Parachoniak, Christine A; Nagle, Julia M; Perera, Rushika M; Lapouge, Marjorie; Deshpande, Vikram; Zhu, Andrew X; Lai, Albert; Min, Bosun; Hoshida, Yujin; Avruch, Joseph; Sia, Daniela; Campreciós, Genís; McClatchey, Andrea I; Llovet, Josep M; Morrissey, David; Raj, Lakshmi; Bardeesy, Nabeel

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

突变型IDH抑制HNF-4α,从而阻断肝细胞分化并促进胆道癌的发生。

Supriya K Saha ,Christine A Parachoniak ,Krishna S Ghanta ,Julien Fitamant ,Kenneth N Ross ,Mortada S Najem ,Sushma Gurumurthy ,Esra A Akbay ,Daniela Sia ,Helena Cornella ,Oriana Miltiadous ,Chad Walesky ,Vikram Deshpande ,Andrew X Zhu ,Aram F Hezel ,Katharine E Yen ,Kimberly S Straley ,Jeremy Travins ,Janeta Popovici-Muller ,Camelia Gliser ,Cristina R Ferrone ,Udayan Apte ,Josep M Llovet ,Kwok-Kin Wong ,Sridhar Ramaswamy ,Nabeel Bardeesy

IDH mutations in liver cell plasticity and biliary cancer

IDH突变与肝细胞可塑性和胆道癌有关

Saha, Supriya K; Parachoniak, Christine A; Bardeesy, Nabeel