Knockout of the intellectual disability-linked gene Hs6st2 in mice decreases heparan sulfate 6-O-sulfation, impairs dendritic spines of hippocampal neurons, and affects memory
敲除小鼠中与智力障碍相关的基因Hs6st2会降低硫酸乙酰肝素6-O-硫酸化水平,损害海马神经元的树突棘,并影响记忆力。
期刊:Glycobiology
影响因子:3.3
doi:10.1093/glycob/cwad095
Moon, Sohyun; Lee, Hiu Ham; Archer-Hartmann, Stephanie; Nagai, Naoko; Mubasher, Zainab; Parappurath, Mahima; Ahmed, Laiba; Ramos, Raddy L; Kimata, Koji; Azadi, Parastoo; Cai, Weikang; Zhao, Jerry Yingtao