日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt

肝脏 BRCA1 通过调节 BHMT 产生矛盾的致癌作用

Ghebreselassie, Martha; Park, Yoo Jin; Nakib, Diana; Dodington, David; Patel, Parasvi; Won, Sohyun; Hakem, Anne; Hakem, Razqallah; MacParland, Sonya; Woo, Minna

PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents.

PRMT1 抑制剂 MS023 抑制 RNA 剪接,使小细胞肺癌对 DNA 损伤剂更加敏感

Aparnathi Mansi K, Ul Haq Sami, St-Germain Jonathan, Nixon Kevin C J, Walton Joseph, Song Lifang, Majeed Safa, Patel Parasvi S, Subramaniam Ratheesh, Philip Vivek, Marcellus Richard, Barsyte-Lovejoy Dalia, Al-Awar Rima, Hakem Razqallah, Arrowsmith Cheryl H, Ailles Laurie, Raught Brian, Lok Benjamin H

Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways

抑制 EZH2 可通过 RNA 和 DNA 传感途径触发病毒模拟,从而靶向非典型畸胎瘤样横纹肌样瘤

Shengrui Feng #, Sajid A Marhon #, Dustin J Sokolowski #, Alister D'Costa, Fraser Soares, Parinaz Mehdipour, Charles Ishak, Helen Loo Yau, Ilias Ettayebi, Parasvi S Patel, Raymond Chen, Jiming Liu, Philip C Zuzarte, King Ching Ho, Ben Ho, Shiyao Ning, Annie Huang, Cheryl H Arrowsmith, Michael D Wils

Unprocessed genomic uracil as a source of DNA replication stress in cancer cells

未加工的基因组尿嘧啶是癌细胞中DNA复制压力的来源

Sneha Saxena ,Christopher S Nabel ,Turner W Seay ,Parasvi S Patel ,Ajinkya S Kawale ,Caroline R Crosby ,Helene Tigro ,Eugene Oh ,Matthew G Vander Heiden ,Aaron N Hata ,Zucai Suo ,Lee Zou

APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability

APOBEC3A 通过 PRIMPOL 诱导 DNA 缺口,并赋予与缺口相关的治疗脆弱性。

Kawale, Ajinkya S; Ran, Xiaojuan; Patel, Parasvi S; Saxena, Sneha; Lawrence, Michael S; Zou, Lee

RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

RNF8 泛素化 XRN2 促进 R 环分解并抑制 BRCA1 突变细胞中的基因组不稳定性

Rehna Krishnan, Mariah Lapierre, Brandon Gautreau, Kevin C J Nixon, Samah El Ghamrasni, Parasvi S Patel, Jun Hao, V Talya Yerlici, Kiran Kumar Naidu Guturi, Jonathan St-Germain, Francesca Mateo, Amine Saad, Arash Algouneh, Rebecca Earnshaw, Duan Shili, Alma Seitova, Joshua Miller, Negin Khosraviani,

Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers

过度的转录复制冲突是 BRCA1 突变癌症的弱点

Parasvi S Patel, Arash Algouneh, Rehna Krishnan, John J Reynolds, Kevin C J Nixon, Jun Hao, Jihoon Lee, Yue Feng, Chehronai Fozil, Mia Stanic, Talya Yerlici, Peiran Su, Fraser Soares, Elisabeth Liedtke, Gil Prive, Gary D Baider, Miquel Angel Pujana, Karim Mekhail, Housheng Hansen He, Anne Hakem, Gra

The RNA m5C modification in R-loops as an off switch of Alt-NHEJ

环中的 RNA m5C 修饰可作为 Alt-NHEJ 的关闭开关

Haibo Yang, Emily M Lachtara, Xiaojuan Ran, Jessica Hopkins, Parasvi S Patel, Xueping Zhu, Yao Xiao, Laiyee Phoon, Boya Gao, Lee Zou, Michael S Lawrence, Li Lan

ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

ATR通过独特的机制保护正在进行和新组装的DNA复制叉。

Wendy Leung ,Antoine Simoneau ,Sneha Saxena ,Jessica Jackson ,Parasvi S Patel ,Mangsi Limbu ,Alessandro Vindigni ,Lee Zou