Pardo Leonardo相关文献与解析，生知库 | 链接生命科学的每一步

Distinctive biochemical properties of the μ-opioid receptor-corticotropin- releasing factor CRF(1) receptor heterotetramer

μ-阿片受体-促肾上腺皮质激素释放因子CRF(1)受体异源四聚体的独特生化特性

doi:10.1016/j.phrs.2025.107904

Sanchez, William N; Moreno, Estefanía; Ciruela-Jardí, Marc; Casajuana-Martín, Nil; Yauch, Anne; Cai, Ning-Sheng; Quiroz, Cesar; Chang, Ya Gin; Casadó, Vicent; Pardo, Leonardo; Plant, Leigh D; Ferré, Sergi

Locomotor activity depends on β-arrestin recruitment by the dopamine D(1) receptor in the striatal D(1)-D(3) receptor heteromer

运动活性依赖于纹状体D(1)-D(3)受体异聚体中多巴胺D(1)受体募集β-arrestin。

期刊:Pharmacological Research

影响因子:10.5

doi:10.1016/j.phrs.2025.107826

Evans, Alexandra H; Ciruela-Jardí, Marc; Rea, William; Keegan, Bradley M; Levinstein, Marjorie R; Bonifazi, Alessandro; Cao, Jianjing; Jackson, Shelley N; Shi, Lei; Casajuana-Martin, Nil; Cai, Ning-Sheng; Casadó, Vicent; Earley, Christopher J; Newman, Amy H; Michaelides, Michael; Pardo, Leonardo; Moreno, Estefanía; Ferré, Sergi

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发表日期：2025

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Design of Small Non-Peptidic Ligands That Alter Heteromerization between Cannabinoid CB(1) and Serotonin 5HT(2A) Receptors

设计能够改变大麻素 CB(1) 和血清素 5HT(2A) 受体之间异源异构化的小型非肽类配体

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.4c01796

Matsoukas, Minos-Timotheos; Ciruela-Jardí, Marc; Gallo, Maria; Ferre, Sergi; Andreu, David; Casadó, Vicent; Pardo, Leonardo; Moreno, Estefanía

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发表日期：2025

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Metadynamics simulations and site-directed mutagenesis determine the binding of cannabidiol to the adenosine A(2A) receptor

元动力学模拟和定点诱变确定了大麻二酚与腺苷A(2A)受体的结合

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.70394

Quintana-Garcia, Aleix; Raïch, Iu; Del Llinas Del Torrent, Claudia; Lillo, Jaume; Casajuana-Martin, Nil; Rebassa, Joan Biel; Navarro, Gemma; Pardo, Leonardo

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发表日期：2025

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Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone

μ-阿片受体配体(S)-美沙酮具有独特的药效学特性和低滥用风险

期刊:Molecular Psychiatry

影响因子:10.1

doi:10.1038/s41380-023-02353-z

Levinstein, Marjorie R; De Oliveira, Paulo A; Casajuana-Martin, Nil; Quiroz, Cesar; Budinich, Reece C; Rais, Rana; Rea, William; Ventriglia, Emilya N; Llopart, Natàlia; Casadó-Anguera, Verònica; Moreno, Estefanía; Walther, Donna; Glatfelter, Grant C; Weinshenker, David; Zarate, Carlos A Jr; Casadó, Vicent; Baumann, Michael H; Pardo, Leonardo; Ferré, Sergi; Michaelides, Michael

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发表日期：2024

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Structural insights into KSHV-GPCR constitutive activation and CXCL1 chemokine recognition

KSHV-GPCR组成型激活和CXCL1趋化因子识别的结构解析

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2403217121

Liu, Aijun; Liu, Yezhou; Llinàs Del Torrent Masachs, Clàudia; Zhang, Weijia; Pardo, Leonardo; Ye, Richard D

Unique effect of clozapine on adenosine A(2A)-dopamine D(2) receptor heteromerization

氯氮平对腺苷A(2A)-多巴胺D(2)受体异源二聚化的独特作用

期刊:Biomedicine & Pharmacotherapy

影响因子:7.5

doi:10.1016/j.biopha.2023.114327

Valle-León, Marta; Casajuana-Martin, Nil; Del Torrent, Claudia Llinas; Argerich, Josep; Gómez-Acero, Laura; Sahlholm, Kristoffer; Ferré, Sergi; Pardo, Leonardo; Ciruela, Francisco

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发表日期：2023

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Clues from a missense mutation of the adenosine A(1) receptor gene associated with early-onset Parkinson's disease

腺苷A(1)受体基因错义突变与早发性帕金森病相关的线索

期刊:Neural Regeneration Research

影响因子:6.7

doi:10.4103/1673-5374.369113

Ferré, Sergi; Pardo, Leonardo; Ciruela, Francisco

The Leu/Val(6.51) Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ(9)-Tetrahydrocannabinol

大麻素受体的Leu/Val(6.51)侧链调节Δ(9)-四氢大麻酚烷基链的结合模式

期刊:Journal of Chemical Information and Modeling

影响因子:5.3

doi:10.1021/acs.jcim.3c01054

Llinas Del Torrent, Claudia; Raïch, Iu; Gonzalez, Angel; Casajuana-Martin, Nil; Lillo, Jaume; Rebassa, Joan Biel; Ferreiro-Vera, Carlos; Sánchez de Medina, Verónica; Franco, Rafael; Navarro, Gemma; Pardo, Leonardo

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发表日期：2023

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Functional significance of opioid receptor homomers and heteromers

阿片受体同源二聚体和异源二聚体的功能意义

Distinctive biochemical properties of the μ-opioid receptor-corticotropin- releasing factor CRF(1) receptor heterotetramer

μ-阿片受体-促肾上腺皮质激素释放因子CRF(1)受体异源四聚体的独特生化特性

Locomotor activity depends on β-arrestin recruitment by the dopamine D(1) receptor in the striatal D(1)-D(3) receptor heteromer

运动活性依赖于纹状体D(1)-D(3)受体异聚体中多巴胺D(1)受体募集β-arrestin。

Design of Small Non-Peptidic Ligands That Alter Heteromerization between Cannabinoid CB(1) and Serotonin 5HT(2A) Receptors

设计能够改变大麻素 CB(1) 和血清素 5HT(2A) 受体之间异源异构化的小型非肽类配体

Metadynamics simulations and site-directed mutagenesis determine the binding of cannabidiol to the adenosine A(2A) receptor

元动力学模拟和定点诱变确定了大麻二酚与腺苷A(2A)受体的结合

Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone

μ-阿片受体配体(S)-美沙酮具有独特的药效学特性和低滥用风险

Structural insights into KSHV-GPCR constitutive activation and CXCL1 chemokine recognition

KSHV-GPCR组成型激活和CXCL1趋化因子识别的结构解析

Unique effect of clozapine on adenosine A(2A)-dopamine D(2) receptor heteromerization

氯氮平对腺苷A(2A)-多巴胺D(2)受体异源二聚化的独特作用

Clues from a missense mutation of the adenosine A(1) receptor gene associated with early-onset Parkinson's disease

腺苷A(1)受体基因错义突变与早发性帕金森病相关的线索

The Leu/Val(6.51) Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ(9)-Tetrahydrocannabinol

大麻素受体的Leu/Val(6.51)侧链调节Δ(9)-四氢大麻酚烷基链的结合模式