日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM

Toll样受体衔接蛋白TRIF和TRAM介导的TIR结构域介导的先天免疫信号传导的结构基础

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2418988122
Manik, Mohammad K; Pan, Mengqi; Xiao, Le; Gu, Weixi; Kim, Hyoyoung; Pospich, Sabrina; Hedger, Andrew; Vajjhala, Parimala R; Lee, Morris Y L; Qian, Xiaoqi; Landsberg, Michael J; Ve, Thomas; Nanson, Jeffrey D; Raunser, Stefan; Stacey, Katryn J; Wu, Hao; Kobe, Bostjan
信号转导
免疫/内分泌
发表日期：2025
文献求助 收藏

Dengue virus NS1 protein does not activate TLR4 and has a modest effect on endothelial monolayer integrity compared to TNF

登革病毒NS1蛋白不激活TLR4，且与TNF相比，对内皮单层完整性的影响较小。

期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1013695
Vajjhala, Parimala R; Kim, Jaehyeon; Pliego Zamora, Adriana; Mostafavi, Helen; Labzin, Larisa I; Stacey, Katryn J
微生物学
TLR4
发表日期：2025
文献求助 收藏

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

o-香兰素与 MAL/TIRAP Lys-210 共价结合，但独立抑制 TLR2

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.6
doi:10.1080/14756366.2024.2313055
Md Habibur Rahaman, Sara J Thygesen, Michael J Maxwell, Hyoyoung Kim, Prerna Mudai, Jeffrey D Nanson, Xinying Jia, Parimala R Vajjhala, Andrew Hedger, Irina Vetter, Thomas Haselhorst, Avril A B Robertson, Brian Dymock, Thomas Ve, Mehdi Mobli, Katryn J Stacey, Bostjan Kobe
TLR2
发表日期：2024
文献求助 收藏

TLR4 phosphorylation at tyrosine 672 activates the ERK/c-FOS signaling module for LPS-induced cytokine responses in macrophages

TLR4 酪氨酸 672 位点的磷酸化可激活 ERK/c-FOS 信号模块，从而引发巨噬细胞中 LPS 诱导的细胞因子反应

期刊:European Journal of Immunology
影响因子:4.5
doi:10.1002/eji.202250056
James E B Curson, Liping Liu, Lin Luo, Timothy W Muusse, Richard M Lucas, Kimberley S Gunther, Parimala R Vajjhala, Rishika Abrol, Alun Jones, Ronan Kapetanovic, Katryn J Stacey, Jennifer L Stow, Matthew J Sweet
免疫
细胞生物学
巨噬细胞
MAPK/ERK
发表日期：2023
文献求助 收藏

Kinetics of severe dengue virus infection and development of gut pathology in mice

小鼠严重登革病毒感染动力学及肠道病理发展

期刊:Journal of Virology
影响因子:3.8
doi:10.1128/jvi.01251-23
Pliego Zamora, Adriana; Kim, Jaehyeon; Vajjhala, Parimala R; Thygesen, Sara J; Watterson, Daniel; Modhiran, Naphak; Bielefeldt-Ohmann, Helle; Stacey, Katryn J
炎症/感染
微生物学
发表日期：2023
文献求助 收藏

Flow cytometric reporter assays provide robust functional analysis of signaling complexes

流式细胞术报告基因检测为信号复合物提供了可靠的功能分析

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1016/j.jbc.2022.102666
Timothy W Muusse, Morris Y L Lee, Hyoyoung Kim, Marie-Odile Parat, Jeffrey D Nanson, Bostjan Kobe, Parimala R Vajjhala, Katryn J Stacey
细胞生物学
其它细胞
发表日期：2022
文献求助 收藏

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

微晶电子衍射和串行飞秒晶体学揭示了MyD88 TIR结构域的高级组装相互作用

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-021-22590-6
Clabbers, Max T B; Holmes, Susannah; Muusse, Timothy W; Vajjhala, Parimala R; Thygesen, Sara J; Malde, Alpeshkumar K; Hunter, Dominic J B; Croll, Tristan I; Flueckiger, Leonie; Nanson, Jeffrey D; Rahaman, Md Habibur; Aquila, Andrew; Hunter, Mark S; Liang, Mengning; Yoon, Chun Hong; Zhao, Jingjing; Zatsepin, Nadia A; Abbey, Brian; Sierecki, Emma; Gambin, Yann; Stacey, Katryn J; Darmanin, Connie; Kobe, Bostjan; Xu, Hongyi; Ve, Thomas
发表日期：2021
文献求助 收藏

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8

Caspase-1 是一种顶端 Caspase，在 AIM2 炎症小体反应中可导致 Caspase-3 裂解，且不依赖于 Caspase-8

期刊:Journal of Molecular Biology
影响因子:4.7
doi:10.1016/j.jmb.2017.10.028
Vitaliya Sagulenko, Nazarii Vitak, Parimala R Vajjhala, James E Vince, Katryn J Stacey
信号转导
炎性小体
发表日期：2018
文献求助 收藏

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

MAL和MyD88依赖性TLR4信号通路中TIR结构域组装形成的结构基础

期刊:Nature Structural & Molecular Biology
影响因子:10.1
doi:10.1038/nsmb.3444
Ve, Thomas; Vajjhala, Parimala R; Hedger, Andrew; Croll, Tristan; DiMaio, Frank; Horsefield, Shane; Yu, Xiong; Lavrencic, Peter; Hassan, Zahid; Morgan, Garry P; Mansell, Ashley; Mobli, Mehdi; O'Carroll, Ailis; Chauvin, Brieuc; Gambin, Yann; Sierecki, Emma; Landsberg, Michael J; Stacey, Katryn J; Egelman, Edward H; Kobe, Bostjan
信号转导
TLR4
发表日期：2017
文献求助 收藏

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

冷冻电镜解析Caspase-8串联DED丝状体的结构揭示了死亡诱导信号复合物的组装和调控机制。

期刊:Molecular Cell
影响因子:16.6
doi:10.1016/j.molcel.2016.09.009
Fu, Tian-Min; Li, Yang; Lu, Alvin; Li, Zongli; Vajjhala, Parimala R; Cruz, Anthony C; Srivastava, Devendra B; DiMaio, Frank; Penczek, Pawel A; Siegel, Richard M; Stacey, Katryn J; Egelman, Edward H; Wu, Hao
信号转导
发表日期：2016
文献求助 收藏