日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes

利用LbNOX异种移植工具扰乱NAD(P)H代谢可延长寿命并减轻与年龄相关的变化

Yadav, Shweta; Pan, Xingxiu; Li, Shengxi; Martin, Paige LaRae; Hoang, Ngoc; Chen, Kejin; Karhadkar, Aditi; Malhotra, Jatin; Zuckerman, Austin L; Munan, Subrata; Klose, Markus K; Wang, Lin; Cracan, Valentin; Parkhitko, Andrey A

Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner.

晚年开始限制膳食蛋氨酸摄入可以促进健康老龄化,且这种促进作用具有性别特异性

Hernández-Arciga Ulalume, Stamenkovic Ceda, Yadav Shweta, Nicoletti Chiara, Albalawy Wafaa N, Al Hammood Farazdaq, Gonzalez Tiffany Fuentes, Naikwadi Maitreyi U, Graham Aidan, Smarz Christian, Little Gabriela J, Williams Sean-Paul G, McMahon Brenda, Sipula Ian J, Vandevender Amber M, Chuan Byron, Cooke Diana, Pinto Antonio F M, Flores Lisa C, Hartman Hannah L, Diedrich Jolene K, Brooke Robert T, Alder Jonathan K, Frahm Krystle A, Pascal Laura E, Stolt Emma, Troensegaard Hannibal, Øvrebø Bente, Elshorbagy Amany, Molina Elsa, Vinknes Kathrine J, Tan Roderick J, Weisz Ora A, Bueno Marta, Eickelberg Oliver, Steinhauser Matthew L, Finkel Toren, Ables Gene P, Ikeno Yuji, Olsen Thomas, Sacco Alessandra, Jurczak Michael J, Sukoff Rizzo Stacey J, Parkhitko Andrey A

Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health

IR或IGF1R基因突变可使小鼠表现出长寿的特征,同时维持其代谢健康。

Hernández-Arciga, Ulalume; Kim, Jun Kyoung; Fisher, Jacob L; Tyshkovskiy, Alexander; Moldakozhayev, Alibek; Hall, Catherine; Ghosh, Souvik; Govindaraj, Yashvandhini; Sipula, Ian J; Kastroll, Jake; Cooke, Diana; Luo, Jinping; Alder, Jonathan K; Rizzo, Stacey J Sukoff; Ables, Gene P; Choi, Eunhee; Gladyshev, Vadim N; Jurczak, Michael J; Tatar, Marc; Parkhitko, Andrey A

Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila

Cyrene:一种新型抗衰老化合物,可延长秀丽隐杆线虫和果蝇的寿命和健康寿命

AlOkda, Abdelrahman; Yadav, Shweta; Pacis, Alain; Jacob-Tomas, Suleima; Parkhitko, Andrey A; Van Raamsdonk, Jeremy M

An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan

一种对胰岛素敏感的果蝇胰岛素样受体突变体通过重塑蛋氨酸代谢来延长寿命

Tatar, Marc; Zheng, Wenjing; Yadav, Shweta; Yamamoto, Rochele; Curtis-Joseph, Noelle; Li, Shengxi; Wang, Lin; Parkhitko, Andrey A

Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila

组织特异性调节 NADH 消耗作为果蝇的抗衰老干预措施

Shweta Yadav, Xingxiu Pan, Shengxi Li, Paige LaRae Martin, Ngoc Hoang, Kejin Chen, Aditi Karhadkar, Jatin Malhotra, Austin L Zuckerman, Subrata Munan, Markus K Klose, Lin Wang, Valentin Cracan, Andrey A Parkhitko

Mutation of an insulin-sensitive Drosophila insulin-like receptor mutant requires methionine metabolism reprogramming to extend lifespan

果蝇胰岛素样受体突变体对胰岛素敏感,其突变需要蛋氨酸代谢重编程才能延长寿命

Tatar, Marc; Zheng, Wenjing; Yadav, Shweta; Yamamoto, Rochele; Curtis-Joseph, Noelle; Li, Shengxi; Wang, Lin; Parkhitko, Andrey A

Unique tau- and synuclein-dependent metabolic reprogramming in neurons distinct from normal aging.

神经元中独特的 tau 蛋白和突触核蛋白依赖性代谢重编程与正常衰老不同

Yadav Shweta, Graham Aidan, Al Hammood Farazdaq, Garbark Chris, Vasudevan Deepika, Pandey Udai, Asara John M, Rajasundaram Dhivyaa, Parkhitko Andrey A

Methionine as a regulator of bone remodeling with fasting

蛋氨酸作为禁食过程中骨重建的调节剂

Tânia Amorim, Naveen Gv Kumar, Natalie L David, William Dion, Trishya Pagadala, Nandini K Doshi, Bokai Zhu, Andrey Parkhitko, Matthew L Steinhauser, Pouneh K Fazeli

Disagreement on foundational principles of biological aging

对生物衰老基本原理的分歧

Gladyshev, Vadim N; Anderson, Benjamin; Barlit, Hanna; Barré, Benjamin; Beck, Samuel; Behrouz, Bahareh; Belsky, Daniel W; Chaix, Amandine; Chamoli, Manish; Chen, Brian H; Cheng, Kaiyang; Chuprin, Jane; Churchill, Gary A; Cipriano, Andrea; Colville, Alex; Deelen, Joris; Deigin, Yuri; Edmonds, KeHuan K; English, Bradley W; Fang, Ruogu; Florea, Michael; Gershteyn, Iosif M; Gill, Diljeet; Goetz, Laura H; Gorbunova, Vera; Griffin, Patrick T; Horvath, Steve; Borch Jensen, Martin; Jin, Xin; Jovanovska, Sara; Kajderowicz, Kathrin M; Kasahara, Tomoko; Kerepesi, Csaba; Kulkarni, Subhash; Labunskyy, Vyacheslav M; Levine, Morgan E; Libert, Sergiy; Lu, J Yuyang; Lu, Yuancheng Ryan; Marioni, Riccardo E; McCoy, Brianah M; Mitchell, Wayne; Moqri, Mahdi; Nasirian, Farzaneh; Niimi, Peter; Oh, Hamilton Se-Hwee; Okundaye, Brian; Parkhitko, Andrey A; Peshkin, Leonid; Petljak, Mia; Poganik, Jesse R; Pridham, Glen; Promislow, Daniel E L; Prusisz, Weronika; Quiniou, Margaux; Raj, Ken; Richard, Daniel; Ricon, Jose Luis; Rutledge, Jarod; Scheibye-Knudsen, Morten; Schork, Nicholas J; Seluanov, Andrei; Shadpour, Michael; Shindyapina, Anastasia V; Shuken, Steven R; Sivakumar, Sruthi; Stoeger, Thomas; Sugiura, Ayumu; Sutton, Nadia R; Suvorov, Alexander; Tarkhov, Andrei E; Teeling, Emma C; Trapp, Alexandre; Tyshkovskiy, Alexander; Unfried, Maximilian; Ward-Caviness, Cavin K; Yim, Sun Hee; Ying, Kejun; Yunes, Jeffrey; Zhang, Bohan; Zhavoronkov, Alex