日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrative single-cell expression and functional studies unravels a sensitization to cytarabine-based chemotherapy through HIF pathway inhibition in AML leukemia stem cells

整合的单细胞表达和功能研究揭示了AML白血病干细胞中HIF通路抑制导致对阿糖胞苷类化疗药物的敏感性增加

Velasco-Hernandez, Talia; Trincado, Juan L; Vinyoles, Meritxell; Closa, Adria; Martínez-Moreno, Alba; Gutiérrez-Agüera, Francisco; Molina, Oscar; Rodríguez-Cortez, Virginia C; Ximeno-Parpal, Pau; Fernández-Fuentes, Narcís; Petazzi, Paolo; Beneyto-Calabuig, Sergi; Velten, Lars; Romecin, Paola; Casquero, Raquel; Abollo-Jiménez, Fernando; de la Guardia, Rafael D; Lorden, Patricia; Bataller, Alex; Lapillonne, Hélène; Stam, Ronald W; Vives, Susana; Torrebadell, Montserrat; Fuster, Jose L; Bueno, Clara; Sarry, Jean-Emmanuel; Eyras, Eduardo; Heyn, Holger; Menéndez, Pablo

Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy

VPS34抑制剂与STING激动剂联用可增强I型干扰素信号传导和抗肿瘤疗效

Yasmin Yu ,Madhumita Bogdan ,Muhammad Zaeem Noman ,Santiago Parpal ,Elisabetta Bartolini ,Kris Van Moer ,Simone Caroline Kleinendorst ,Kristine Bilgrav Saether ,Lionel Trésaugues ,Camilla Silvander ,Johan Lindström ,Jodi Simeon ,Mary Jane Timson ,Hikmat Al-Hashimi ,Bryan D Smith ,Daniel L Flynn ,Andrey Alexeyenko ,Jenny Viklund ,Martin Andersson ,Jessica Martinsson ,Katja Pokrovskaja Tamm ,Angelo De Milito ,Bassam Janji

Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34

通过阻断自噬相关蛋白PIK3C3/VPS34的活性,点燃冷肿瘤中的“火焰”,从而改善癌症免疫疗法。

Janji, Bassam; Hasmim, Meriem; Parpal, Santiago; De Milito, Angelo; Berchem, Guy; Noman, Muhammad Zaeem

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy

抑制Vps34可将冷肿瘤重编程为热炎症肿瘤,并改善抗PD-1/PD-L1免疫疗法。

Muhammad Zaeem Noman ,Santiago Parpal ,Kris Van Moer ,Malina Xiao ,Yasmin Yu ,Jenny Viklund ,Angelo De Milito ,Meriem Hasmim ,Martin Andersson ,Ravi K Amaravadi ,Jessica Martinsson ,Guy Berchem ,Bassam Janji

Firing up the cold tumors by targeting Vps34

通过靶向Vps34激活冷肿瘤

Janji, Bassam; Hasmim, Meriem; Parpal, Santiago; Berchem, Guy; Noman, Muhammad Zaeem

Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production

第二代 γ-分泌酶调节剂对 Notch β 和 Aβ 的产生有不同的调节作用

Johanna Wanngren, Jan Ottervald, Santiago Parpal, Erik Portelius, Kia Strömberg, Tomas Borgegård, Rebecka Klintenberg, Anders Juréus, Jenny Blomqvist, Kaj Blennow, Henrik Zetterberg, Johan Lundkvist, Susanne Rosqvist, Helena Karlström

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy

阿尔茨海默病:保留早老素2的γ-分泌酶抑制剂是一种耐受性良好的降低Aβ肽水平的策略

Borgegård, Tomas; Gustavsson, Susanne; Nilsson, Charlotte; Parpal, Santiago; Klintenberg, Rebecka; Berg, Anna-Lena; Rosqvist, Susanne; Serneels, Lutgarde; Svensson, Samuel; Olsson, Fredrik; Jin, Shaobo; Yan, Hongmei; Wanngren, Johanna; Jureus, Anders; Ridderstad-Wollberg, Anna; Wollberg, Patrik; Stockling, Kenneth; Karlström, Helena; Malmberg, Asa; Lund, Johan; Arvidsson, Per I; De Strooper, Bart; Lendahl, Urban; Lundkvist, Johan

First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms

第一代和第二代 γ-分泌酶调节剂 (GSM) 通过不同的机制调节淀粉样蛋白-β (Aβ) 肽的产生

Tomas Borgegard, Anders Juréus, Fredrik Olsson, Susanne Rosqvist, Alan Sabirsh, Didier Rotticci, Kim Paulsen, Rebecka Klintenberg, Hongmei Yan, Magnus Waldman, Kia Stromberg, Johan Nord, Jonas Johansson, Anna Regner, Santiago Parpal, David Malinowsky, Ann-Cathrin Radesater, Tingsheng Li, Rajeshwar S

The young, the weak and the sick: evidence of natural selection by predation

幼小、体弱和患病:捕食行为的自然选择证据

Genovart, Meritxell; Negre, Nieves; Tavecchia, Giacomo; Bistuer, Ana; Parpal, Luís; Oro, Daniel

Isolation of phosphooligosaccharide/phosphoinositol glycan from caveolae and cytosol of insulin-stimulated cells

从胰岛素刺激细胞的胞内小窝和胞质溶胶中分离磷酸寡糖/磷酸肌醇聚糖

Parpal, S; Gustavsson, J; Strålfors, P