日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation

PARP1-HPF1 在缺口 DNA 上的结构和动力学揭示了一种急性局部 ADP 核糖基化的机制

Sverzhinsky, Aleksandr; Xue, Huijun; Langelier, Marie-France; Muniz Corrêa, Marcelo V; Del Mundo, Joshua; Classen, Scott; Hammel, Michal; Rothenberg, Eli; Pascal, John M

PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly

PARP4 对 PIDD1 进行 ADP 核糖基化修饰,完成磷酸化/SUMO/PAR 化级联反应,从而调控 PIDDosome 的组装。

Shah, Richa B; Li, Yuanyuan; Person, Ashley; Frigon, Léonie; Ðukić, Nina; Kini, Ela; Chen, Raymond; Pascal, John M; Cohen, Michael S; Ahel, Ivan; Haley, John D; Sidi, Samuel

Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13

聚(ADP-核糖)与PARP13相互作用调控应激颗粒的成熟和动态变化

Cheng, Shang-Jung; Gafaar, Temitope; Kuttiyatveetil, Jijin R A; Sverzhinsky, Aleksandr; Chen, Carla; Xu, Minghui; Lilley, Allison; Pascal, John M; Leung, Anthony K L

PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex.

PARP1 和 PARylation 通过稳定 CSB-RNAPII 复合物来促进转录偶联的 DNA 修复。

Robu Mihaela, Shah Rashmi G, van den Heuvel Diana, Coulombe Yan, Bazin Marc, van der Woude Melanie, Kragten Angela, Lans Hannes, Pascal John M, Masson Jean-Yves, Luijsterburg Martijn S, Shah Girish M

Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4

人类PARP4中核酸结合BRCT结构域的晶体结构和诱变

Frigon, Léonie; Pascal, John M

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose).

PARP酶从头合成不含蛋白质的聚(ADP-核糖)

Langelier Marie-France, Mirhasan Manija, Gilbert Karine, Sverzhinksy Aleksandr, Furtos Alexandra, Pascal John M

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

临床PARP抑制剂通过变构作用诱导PARP2在DNA上的滞留。

Langelier, Marie-France; Lin, Xiaohui; Zha, Shan; Pascal, John M

PARP-nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance

PARP与核酸的相互作用:变构信号传导、PARP抑制剂类型、DNA桥和病毒RNA监测

Pascal, John M

ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification

ADP-核糖对基因组稳定性和PARP酶在DNA损伤位点的捕获的贡献;成熟修饰的范式转变

Rouleau-Turcotte, Élise; Pascal, John M

Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.

捕捉到的 PARP1 活性状态快照揭示了 PARP1 变构的机制

Rouleau-Turcotte Élise, Krastev Dragomir B, Pettitt Stephen J, Lord Christopher J, Pascal John M