日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours

转录免疫基因组学分析揭示儿童神经系统肿瘤中存在不同的免疫簇

Arash Nabbi #, Pengbo Beck #, Alberto Delaidelli, Derek A Oldridge, Sumedha Sudhaman, Kelsey Zhu, S Y Cindy Yang, David T Mulder, Jeffrey P Bruce, Joseph N Paulson, Pichai Raman, Yuankun Zhu, Adam C Resnick, Poul H Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D Johann

Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics

复发性非典型畸胎瘤样/横纹肌样瘤 (AT/RT) 在组织学、表观遗传学、拷贝数分析和转录组学上表现出离散的进展特征

Pascal D Johann #, Lea Altendorf #, Emma-Maria Efremova, Till Holsten, Mona Steinbügl, Karolina Nemes, Alicia Eckhardt, Catena Kresbach, Michael Bockmayr, Arend Koch, Christine Haberler, Manila Antonelli, John DeSisto, Martin U Schuhmann, Peter Hauser, Reiner Siebert, Susanne Bens, Marcel Kool, Adam

ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance

ATRT-SHH 包含三个分子亚型,具有特征性的临床和组织病理学特征以及预后意义

Aniello Federico #, Christian Thomas #, Katarzyna Miskiewicz, Niklas Woltering, Francesca Zin, Karolina Nemes, Brigitte Bison, Pascal D Johann, Debra Hawes, Susanne Bens, Uwe Kordes, Steffen Albrecht, Hildegard Dohmen, Peter Hauser, Kathy Keyvani, Frank K H van Landeghem, Eva Løbner Lund, David Sche

Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors

抑制核输出可恢复截短的SMARCB1/INI1蛋白在非典型畸胎瘤/横纹肌样瘤分子亚群中的核定位和残余抑癌功能。

Rajiv Pathak # ,Francesca Zin # ,Christian Thomas ,Susanne Bens ,Tenzin Gayden ,Jason Karamchandani ,Roy W Dudley ,Karolina Nemes ,Pascal D Johann ,Florian Oyen ,Uwe Kordes ,Nada Jabado ,Reiner Siebert ,Werner Paulus ,Marcel Kool ,Michael C Frühwald ,Steffen Albrecht ,Ganjam V Kalpana # ,Martin Hasselblatt #

Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury

在INI1缺陷型儿童脊索瘤中,对纳武利尤单抗的临床反应与brachyury的免疫原性识别相关。

Laura M Williamson ,Craig M Rive ,Daniela Di Francesco ,Emma Titmuss ,Hye-Jung E Chun ,Scott D Brown ,Katy Milne ,Erin Pleasance ,Anna F Lee ,Stephen Yip ,Daniel G Rosenbaum ,Martin Hasselblatt ,Pascal D Johann ,Marcel Kool ,Melissa Harvey ,David Dix ,Daniel J Renouf ,Robert A Holt ,Brad H Nelson ,Martin Hirst ,Steven J M Jones ,Janessa Laskin ,Shahrad R Rassekh ,Rebecca J Deyell ,Marco A Marra

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

局部应用B7-H3靶向CAR T细胞治疗非典型畸胎瘤/横纹肌样瘤

Johanna Theruvath,Elena Sotillo,Christopher W Mount,Claus Moritz Graef,Alberto Delaidelli,Sabine Heitzeneder,Louai Labanieh,Shaurya Dhingra,Amaury Leruste,Robbie G Majzner,Peng Xu,Sabine Mueller,Derek W Yecies,Martina A Finetti,Daniel Williamson,Pascal D Johann,Marcel Kool,Stefan Pfister,Martin Hasselblatt,Michael C Frühwald,Olivier Delattre,Didier Surdez,Franck Bourdeaut,Stephanie Puget,Sakina Zaidi,Siddhartha S Mitra,Samuel Cheshier,Poul H Sorensen,Michelle Monje,Crystal L Mackall

SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability

SMARCB1 缺失与神经元分化状态相互作用,阻碍成熟并影响细胞稳定性

Alison D Parisian, Tomoyuki Koga, Shunichiro Miki, Pascal D Johann, Marcel Kool, John R Crawford, Frank B Furnari

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

对非典型畸胎瘤/横纹肌样瘤染色质状态的全面分析揭示了SWI/SNF和Polycomb在基因调控中的不同作用

Serap Erkek ,Pascal D Johann ,Martina A Finetti ,Yiannis Drosos ,Hsien-Chao Chou ,Marc Zapatka ,Dominik Sturm ,David T W Jones ,Andrey Korshunov ,Marina Rhyzova ,Stephan Wolf ,Jan-Philipp Mallm ,Katja Beck ,Olaf Witt ,Andreas E Kulozik ,Michael C Frühwald ,Paul A Northcott ,Jan O Korbel ,Peter Lichter ,Roland Eils ,Amar Gajjar ,Charles W M Roberts ,Daniel Williamson ,Martin Hasselblatt ,Lukas Chavez ,Stefan M Pfister ,Marcel Kool

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

非典型畸胎瘤样/横纹肌样瘤由三个具有不同增强子景观的表观遗传亚群组成

Pascal D Johann, Serap Erkek, Marc Zapatka, Kornelius Kerl, Ivo Buchhalter, Volker Hovestadt, David T W Jones, Dominik Sturm, Carl Hermann, Maia Segura Wang, Andrey Korshunov, Marina Rhyzova, Susanne Gröbner, Sebastian Brabetz, Lukas Chavez, Susanne Bens, Stefan Gröschel, Fabian Kratochwil, Andrea W