日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

一种带有血脑屏障转运载体的TREM2激活抗体可增强阿尔茨海默病模型中的小胶质细胞代谢。

Bettina van Lengerich # ,Lihong Zhan # ,Dan Xia # ,Darren Chan ,David Joy ,Joshua I Park ,David Tatarakis ,Meredith Calvert ,Selina Hummel ,Steve Lianoglou ,Michelle E Pizzo ,Rachel Prorok ,Elliot Thomsen ,Laura M Bartos ,Philipp Beumers ,Anja Capell ,Sonnet S Davis ,Lis de Weerd ,Jason C Dugas ,Joseph Duque ,Timothy Earr ,Kapil Gadkar ,Tina Giese ,Audrey Gill ,Johannes Gnörich ,Connie Ha ,Malavika Kannuswamy ,Do Jin Kim ,Sebastian T Kunte ,Lea H Kunze ,Diana Lac ,Kendra Lechtenberg ,Amy Wing-Sze Leung ,Chun-Chi Liang ,Isabel Lopez ,Paul McQuade ,Anuja Modi ,Vanessa O Torres ,Hoang N Nguyen ,Ida Pesämaa ,Nicholas Propson ,Marvin Reich ,Yaneth Robles-Colmenares ,Kai Schlepckow ,Luna Slemann ,Hilda Solanoy ,Jung H Suh ,Robert G Thorne ,Chandler Vieira ,Karin Wind-Mark ,Ken Xiong ,Y Joy Yu Zuchero ,Dolo Diaz ,Mark S Dennis ,Fen Huang ,Kimberly Scearce-Levie ,Ryan J Watts ,Christian Haass ,Joseph W Lewcock ,Gilbert Di Paolo ,Matthias Brendel ,Pascal E Sanchez ,Kathryn M Monroe

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

新型应用程序敲入小鼠模型展现了淀粉样蛋白病理的关键特征,并揭示了小胶质细胞严重的代谢紊乱。

Dan Xia # ,Steve Lianoglou # ,Thomas Sandmann ,Meredith Calvert ,Jung H Suh ,Elliot Thomsen ,Jason Dugas ,Michelle E Pizzo ,Sarah L DeVos ,Timothy K Earr ,Chia-Ching Lin ,Sonnet Davis ,Connie Ha ,Amy Wing-Sze Leung ,Hoang Nguyen ,Roni Chau ,Ernie Yulyaningsih ,Isabel Lopez ,Hilda Solanoy ,Shababa T Masoud ,Chun-Chi Liang ,Karin Lin ,Giuseppe Astarita ,Nathalie Khoury ,Joy Yu Zuchero ,Robert G Thorne ,Kevin Shen ,Stephanie Miller ,Jorge J Palop ,Dylan Garceau ,Michael Sasner ,Jennifer D Whitesell ,Julie A Harris ,Selina Hummel ,Johannes Gnörich ,Karin Wind ,Lea Kunze ,Artem Zatcepin ,Matthias Brendel ,Michael Willem ,Christian Haass ,Daniel Barnett ,Till S Zimmer ,Anna G Orr ,Kimberly Scearce-Levie ,Joseph W Lewcock ,Gilbert Di Paolo ,Pascal E Sanchez

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

利用可穿透血脑屏障的生物制剂挽救由 Grn 功能丧失引起的溶酶体贮积症

Todd Logan ,Matthew J Simon ,Anil Rana ,Gerald M Cherf ,Ankita Srivastava ,Sonnet S Davis ,Ray Lieh Yoon Low ,Chi-Lu Chiu ,Meng Fang ,Fen Huang ,Akhil Bhalla ,Ceyda Llapashtica ,Rachel Prorok ,Michelle E Pizzo ,Meredith E K Calvert ,Elizabeth W Sun ,Jennifer Hsiao-Nakamoto ,Yashas Rajendra ,Katrina W Lexa ,Devendra B Srivastava ,Bettina van Lengerich ,Junhua Wang ,Yaneth Robles-Colmenares ,Do Jin Kim ,Joseph Duque ,Melina Lenser ,Timothy K Earr ,Hoang Nguyen ,Roni Chau ,Buyankhishig Tsogtbaatar ,Ritesh Ravi ,Lukas L Skuja ,Hilda Solanoy ,Howard J Rosen ,Bradley F Boeve ,Adam L Boxer ,Hilary W Heuer ,Mark S Dennis ,Mihalis S Kariolis ,Kathryn M Monroe ,Laralynne Przybyla ,Pascal E Sanchez ,Rene Meisner ,Dolores Diaz ,Kirk R Henne ,Ryan J Watts ,Anastasia G Henry ,Kannan Gunasekaran ,Giuseppe Astarita ,Jung H Suh ,Joseph W Lewcock ,Sarah L DeVos ,Gilbert Di Paolo

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1

人类 APP 转基因小鼠的行为和神经网络异常与 App 敲入小鼠相似,并且受家族性阿尔茨海默病突变的调节,而不是受 BACE1 抑制的调节

Erik C B Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E Sanchez, Biljana Djukic, Isabel Lopez, Xinxing Yu, Michael Gill, Weiping Zhang, Jeanne T Paz, Jorge J Palop, Lennart Mucke

Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia

α-突触核蛋白转基因小鼠和人类路易体痴呆症的网络功能障碍

Meaghan Morris, Pascal E Sanchez, Laure Verret, Alexander J Beagle, Weikun Guo, Dena Dubal, Kamalini G Ranasinghe, Akihiko Koyama, Kaitlyn Ho, Gui-Qiu Yu, Keith A Vossel, Lennart Mucke

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice

寿命延长因子 klotho 可防止 hAPP 转基因小鼠死亡并增强认知能力

Dena B Dubal, Lei Zhu, Pascal E Sanchez, Kurtresha Worden, Lauren Broestl, Erik Johnson, Kaitlyn Ho, Gui-Qiu Yu, Daniel Kim, Alexander Betourne, Makoto Kuro-O, Eliezer Masliah, Carmela R Abraham, Lennart Mucke

Tau reduction prevents disease in a mouse model of Dravet syndrome

Tau 减少可预防 Dravet 综合征小鼠模型中的疾病

Ania L Gheyara, Ravikumar Ponnusamy, Biljana Djukic, Ryan J Craft, Kaitlyn Ho, Weikun Guo, Mariel M Finucane, Pascal E Sanchez, Lennart Mucke

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

生理性脑活动导致神经元 DNA 双链断裂,并因淀粉样β蛋白而加剧

Elsa Suberbielle, Pascal E Sanchez, Alexxai V Kravitz, Xin Wang, Kaitlyn Ho, Kirsten Eilertson, Nino Devidze, Anatol C Kreitzer, Lennart Mucke