日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel gRNA design pipeline to develop broad-spectrum CRISPR/Cas9 gRNAs for safe targeting of the HIV-1 quasispecies in patients

新型 gRNA 设计流程,用于开发广谱 CRISPR/Cas9 gRNA,以安全靶向患者体内的 HIV-1 准物种

Neil T Sullivan, Will Dampier, Cheng-Han Chung, Alexander G Allen, Andrew Atkins, Vanessa Pirrone, Greg Homan, Shendra Passic, Jean Williams, Wen Zhong, Katherine Kercher, Mathew Desimone, Luna Li, Gregory C Antell, Joshua Chang Mell, Garth D Ehrlich, Zsofia Szep, Jeffrey M Jacobson, Michael R Nonne

Investigating the distribution of HIV-1 Tat lengths present in the Drexel Medicine CARES cohort

调查德雷克塞尔医学 CARES 队列中 HIV-1 Tat 长度的分布情况

Link, Robert W; Mele, Anthony R; Antell, Gregory C; Pirrone, Vanessa; Zhong, Wen; Kercher, Katherine; Passic, Shendra; Szep, Zsofia; Malone, Kim; Jacobson, Jeffrey M; Dampier, Will; Wigdahl, Brian; Nonnemacher, Michael R

Broad-Spectrum and Personalized Guide RNAs for CRISPR/Cas9 HIV-1 Therapeutics

用于 CRISPR/Cas9 HIV-1 疗法的广谱和个性化向导 RNA

Dampier, Will; Sullivan, Neil T; Mell, Joshua Chang; Pirrone, Vanessa; Ehrlich, Garth D; Chung, Cheng-Han; Allen, Alexander G; DeSimone, Mathew; Zhong, Wen; Kercher, Katherine; Passic, Shendra; Williams, Jean W; Szep, Zsofia; Khalili, Kamel; Jacobson, Jeffrey M; Nonnemacher, Michael R; Wigdahl, Brian

Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status

HIV-1 Vpr 中的特定氨基酸与患者神经认知状态的差异显著相关

Will Dampier ,Gregory C Antell ,Benjamas Aiamkitsumrit ,Michael R Nonnemacher ,Jeffrey M Jacobson ,Vanessa Pirrone ,Wen Zhong ,Katherine Kercher ,Shendra Passic ,Jean W Williams ,Tony James ,Kathryn N Devlin ,Tania Giovannetti ,David J Libon ,Zsofia Szep ,Garth D Ehrlich ,Brian Wigdahl ,Fred C Krebs

Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences

R5 和 X4 相关 HIV-1 Vpr 序列的比较分析表明氨基酸使用存在差异

Antell, Gregory C; Dampier, Will; Aiamkitsumrit, Benjamas; Nonnemacher, Michael R; Pirrone, Vanessa; Zhong, Wen; Kercher, Katherine; Passic, Shendra; Williams, Jean; Liu, Yucheng; James, Tony; Jacobson, Jeffrey M; Szep, Zsofia; Wigdahl, Brian; Krebs, Fred C

Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures

利用 HIV-1 包膜 V3 识别 X4 和 R5 特异性 Tat 和 LTR 序列特征

Antell, Gregory C; Dampier, Will; Aiamkitsumrit, Benjamas; Nonnemacher, Michael R; Jacobson, Jeffrey M; Pirrone, Vanessa; Zhong, Wen; Kercher, Katherine; Passic, Shendra; Williams, Jean W; Schwartz, Gregory; Hershberg, Uri; Krebs, Fred C; Wigdahl, Brian

Mitochondrial Haplogroup Influences Motor Function in Long-Term HIV-1-Infected Individuals

线粒体单倍群影响长期感染HIV-1患者的运动功能

Azar, Ashley; Devlin, Kathryn; Mell, Joshua Chang; Giovannetti, Tania; Pirrone, Vanessa; Nonnemacher, Michael R; Passic, Shendra; Kercher, Katherine; Williams, Jean W; Jacobson, Jeffery M; Wigdahl, Brian; Dampier, William; Libon, David J; Sell, Christian

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity

HIV-1启动子单核苷酸多态性与临床疾病严重程度相关

Nonnemacher, Michael R; Pirrone, Vanessa; Feng, Rui; Moldover, Brian; Passic, Shendra; Aiamkitsumrit, Benjamas; Dampier, Will; Wojno, Adam; Kilareski, Evelyn; Blakey, Brandon; Ku, Tse-Sheun Jade; Shah, Sonia; Sullivan, Neil T; Jacobson, Jeffrey M; Wigdahl, Brian

HIV-1 Genetic Variation Resulting in the Development of New Quasispecies Continues to Be Encountered in the Peripheral Blood of Well-Suppressed Patients

在病毒抑制良好的患者的外周血中,仍然能够检测到导致新准种产生的HIV-1基因变异。

Dampier, Will; Nonnemacher, Michael R; Mell, Joshua; Earl, Joshua; Ehrlich, Garth D; Pirrone, Vanessa; Aiamkitsumrit, Benjamas; Zhong, Wen; Kercher, Katherine; Passic, Shendra; Williams, Jean W; Jacobson, Jeffrey M; Wigdahl, Brian

Defining differential genetic signatures in CXCR4- and the CCR5-utilizing HIV-1 co-linear sequences

定义利用 CXCR4 和 CCR5 的 HIV-1 共线性序列中的差异性遗传特征

Aiamkitsumrit, Benjamas; Dampier, Will; Martin-Garcia, Julio; Nonnemacher, Michael R; Pirrone, Vanessa; Ivanova, Tatyana; Zhong, Wen; Kilareski, Evelyn; Aldigun, Hazeez; Frantz, Brian; Rimbey, Matthew; Wojno, Adam; Passic, Shendra; Williams, Jean W; Shah, Sonia; Blakey, Brandon; Parikh, Nirzari; Jacobson, Jeffrey M; Moldover, Brian; Wigdahl, Brian