日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Recent advances in structural investigations of cancer antigen mesothelin and its interactions with therapeutic antibodies

癌症抗原间皮素的结构研究及其与治疗性抗体的相互作用的最新进展

期刊:Antibody Therapeutics
影响因子:4.5
doi:10.1093/abt/tbaf028
Zhan, Jingyu; Ho, Mitchell; Esser, Lothar; Maslanka, Carolyn A; Pastan, Ira; Xia, Di
肿瘤
肿瘤免疫
发表日期：2026
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RO4, a high-affinity humanized antibody against the juxtamembrane region of mesothelin for targeted cancer therapy.

RO4 是一种针对间皮素近膜区的高亲和力人源化抗体，用于靶向癌症治疗。

期刊:Antibody Therapeutics
影响因子:4.5
doi:10.1093/abt/tbaf022
Onda Masanori, Liu Xiufen, Liu Wenlong, Zhan Jingyu, Maslanka Carolyn A, Xia Di, Ho Mitchell, Pastan Ira
肿瘤
肿瘤免疫
发表日期：2026
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Complete Response in Hairy Cell Leukemia to Anti-CD22 CAR T-Cell Therapy

抗CD22 CAR T细胞疗法治疗毛细胞白血病可获得完全缓解

期刊:Jco Precision Oncology
影响因子:5.6
doi:10.1200/PO-25-00269
Kreitman, Robert J; Schroeder, Brett; Arons, Evgeny; Yuan, Constance; Wang, Hao-Wei; Raffeld, Mark; Xi, Liqiang; Pittaluga, Stefania; Zhou, Hong; Gould, Mory; Shpilman, Isaac; Turkbey, Evrim; Calvo, Katherine R; James, Lacey; Ortiz, Olena Sierra; Highfill, Steve; Stroncek, David; Yates, Bonnie; Pastan, Ira; Shah, Nirali N
免疫/内分泌
细胞生物学
T细胞
CD22
白血病
CD2
T细胞
发表日期：2025
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A new treatment for canine B-cell lymphoma based on a recombinant single-domain antibody immunotoxin derived from Pseudomonas aeruginosa exotoxin A

一种基于源自铜绿假单胞菌外毒素A的重组单域抗体免疫毒素的犬B细胞淋巴瘤新疗法

期刊:Frontiers in Veterinary Science
影响因子:2.9
doi:10.3389/fvets.2025.1491934
André, Ana S; Dias, Joana N R; Moutinho, Isa; Loureiro, Joana; Leonardo, Ana; Nogueira, Sara; Marimon, Rafaela P; Bule, Pedro; Correia, Jorge; Malhó, Rui; Gano, Lurdes; Correia, João D G; Gil, Solange; Gonçalves, João; Pastan, Ira; Tavares, Luís; Aires-da-Silva, Frederico
B细胞
细胞生物学
淋巴瘤
免疫/内分泌
发表日期：2025
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Mapping drug distribution using CT imaging following direct tissue injection in ex vivo liver: informing clinical implementation

利用CT成像技术绘制离体肝脏组织内直接注射药物后的药物分布图：为临床应用提供信息

期刊:
影响因子:
doi:10.1007/s44343-025-00027-x
Morhard, Robert; Mauda-Havakuk, Michal; Delgado, Jose F; Kassin, Michael T; Ghafoor, Azam; Pastan, Ira; Hassan, Raffit; Karanian, John W; Pritchard, William F; Wood, Bradford J; Mikhail, Andrew S
发表日期：2025
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A Bispecific Antibody That Targets the Membrane-Proximal Region of Mesothelin and Retains High Anticancer Activity in the Presence of Shed Mesothelin.

一种靶向间皮素膜近端区域的双特异性抗体，即使在脱落的间皮素存在的情况下仍保持较高的抗癌活性

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-23-0233
Chakraborty Anirban, Onda Masanori, O'Shea Tara, Wei Junxia, Liu Xiufen, Bera Tapan K, Pastan Ira
肿瘤
肿瘤免疫
发表日期：2024
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Tofacitinib to prevent anti-drug antibody formation against LMB-100 immunotoxin in patients with advanced mesothelin-expressing cancers.

托法替尼用于预防晚期间皮素表达癌症患者体内针对LMB-100免疫毒素的抗药抗体形成

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2024.1386190
Skorupan Nebojsa, Peer Cody J, Zhang Xianyu, Choo-Wosoba Hyoyoung, Ahmad Mehwish I, Lee Min-Jung, Rastogi Shraddha, Sato Nahoko, Yu Yunkai, Pegna Guillaume Joe, Steinberg Seth M, Kalsi Shelley S, Cao Liang, Figg William D, Trepel Jane B, Pastan Ira, FitzGerald David, Alewine Christine
肿瘤
肿瘤免疫
发表日期：2024
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Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models

免疫毒素-αCD40疗法可激活先天性和适应性免疫，并在胶质母细胞瘤模型中产生持久的抗肿瘤反应。

期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.abn5649
Parker, Scott; McDowall, Charlotte; Sanchez-Perez, Luis; Osorio, Cristina; Duncker, Patrick C; Briley, Aaron; Swartz, Adam M; Herndon, James E 2nd; Yu, Yen-Rei A; McLendon, Roger E; Tedder, Thomas F; Desjardins, Annick; Ashley, David M; Gunn, Michael Dee; Enterline, David S; Knorr, David A; Pastan, Ira H; Nair, Smita K; Bigner, Darell D; Chandramohan, Vidyalakshmi
肿瘤
T细胞
肿瘤免疫
CD40
细胞生物学
CD4
免疫/内分泌
发表日期：2023
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Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies

癌症抗原间皮素及其与治疗性抗体的复合物的结构

期刊:Cancer Research Communications
影响因子:3.3
doi:10.1158/2767-9764.CRC-22-0306
Zhan, Jingyu; Lin, Dong; Watson, Nathan; Esser, Lothar; Tang, Wai Kwan; Zhang, Alex; Liu, Xiufen; Hassan, Raffit; Gleinich, Anne; Shajahan, Asif; Azadi, Parastoo; Pastan, Ira; Xia, Di
肿瘤
肿瘤免疫
发表日期：2023
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Systemic immune changes accompany combination treatment with immunotoxin LMB-100 and nab-paclitaxel

免疫毒素LMB-100与白蛋白紫杉醇联合治疗会伴随全身免疫变化。

期刊:Cancer Medicine
影响因子:3.1
doi:10.1002/cam4.5290
Pegna, Guillaume Joe; Lee, Min-Jung; Peer, Cody J; Ahmad, Mehwish I; Venzon, David J; Yu, Yunkai; Yuno, Akira; Steinberg, Seth M; Cao, Liang; Figg, William D; Donahue, Renee N; Hassan, Raffit; Pastan, Ira; Trepel, Jane B; Alewine, Christine
免疫/内分泌
发表日期：2023
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