Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer's disease
小鼠蓝斑核中的致病性tau蛋白会导致去甲肾上腺素能过度活跃和类似于早期阿尔茨海默病的神经精神表型。
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doi:10.64898/2026.01.30.702923
Korukonda, Anu; Blankenship, Harris E; Kam, Korey; Kour, Dilpreet; Espinosa-Garcia, Claudia; Jang, Wooyoung Eric; Srivastava, Upasna; Mulvey, Bernard; Tish, Margaret M; Witztum, Ronit; Ramelow, Christina C; Pate, Brittany S; Liles, L Cameron; Lu, Linyue; Atallah, Jake; Guo, Eugene; Martinowich, Keri; Sharpe, Amanda L; Varga, Andrew W; Rangaraju, Srikant; Beckstead, Michael J; Weinshenker, David