Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521)
白细胞功能相关抗原-1 (LFA-1) 的小分子拮抗剂：结构-活性关系导致鉴定 6-((5S,9R)-9-(4-氰基苯基)-3-(3,5-二氯苯基)-1-甲基-2,4-二氧代-1,3,7-三氮杂螺[4.4]壬-7-基)烟酸 (BMS-688521)
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm100348u
Scott H Watterson, Zili Xiao, Dharmpal S Dodd, David R Tortolani, Wayne Vaccaro, Dominique Potin, Michele Launay, Dawn K Stetsko, Stacey Skala, Patric M Davis, Deborah Lee, Xiaoxia Yang, Kim W McIntyre, Praveen Balimane, Karishma Patel, Zheng Yang, Punit Marathe, Pathanjali Kadiyala, Andrew J Tebben
