Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model
发现用于治疗恰加斯病的药物 IID432:一种氰基三唑类锥虫拓扑异构酶 II 抑制剂,在慢性感染模型中短期治疗后可实现完全治愈
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02459
René, Olivier; Saldivia, Manuel; Dauphinais, Maxime; Zhang, Lei; Hollingsworth, Scott A; Jiricek, Jan; Koester, Dennis C; Miller, Sarah L; Williams, Sarah L; Ng, Pearly S; Patra, Debjani; Jumani, Rajiv S; Baxley, Grace M; Osborne, Colin S; Chen, Ying-Bo; Chen, Yen-Liang; Cheung, Harry; Lakshminarayana, Suresh B; Galarneau, Jean-René; Diagana, Thierry T; Sarko, Christopher; Rao, Srinivasa P S