日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model

发现用于治疗恰加斯病的药物 IID432:一种氰基三唑类锥虫拓扑异构酶 II 抑制剂,在慢性感染模型中短期治疗后可实现完全治愈

René, Olivier; Saldivia, Manuel; Dauphinais, Maxime; Zhang, Lei; Hollingsworth, Scott A; Jiricek, Jan; Koester, Dennis C; Miller, Sarah L; Williams, Sarah L; Ng, Pearly S; Patra, Debjani; Jumani, Rajiv S; Baxley, Grace M; Osborne, Colin S; Chen, Ying-Bo; Chen, Yen-Liang; Cheung, Harry; Lakshminarayana, Suresh B; Galarneau, Jean-René; Diagana, Thierry T; Sarko, Christopher; Rao, Srinivasa P S

Cryo-EM structures of Nipah virus polymerases and high-throughput RdRp assay development enable anti-NiV drug discovery.

尼帕病毒聚合酶的冷冻电镜结构和高通量 RdRp 检测方法的开发,为抗尼帕病毒药物的发现提供了可能

Chen Zhenhang, Quirit Dudley Jeanne, Deniston Colin, Buffalo Cosmo Z, Patra Debjani, Cao Dongdong, Hunt Julia, Rohaim Ahmed, Sengupta Debapriya, Wen Lan, Tsang Tiffany, Xie Lili, DiDonato Michael, Spraggon Glen, Clifton Matthew C, Jarrousse Nadine, Straimer Judith, Liang Bo

Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)

发现用于治疗人类非洲锥虫病(HAT)的新型喹啉类蛋白酶体抑制剂

Koester, Dennis C; Marx, Vanessa M; Williams, Sarah; Jiricek, Jan; Dauphinais, Maxime; René, Olivier; Miller, Sarah L; Zhang, Lei; Patra, Debjani; Chen, Yen-Liang; Cheung, Harry; Gable, Jonathan; Lakshminarayana, Suresh B; Osborne, Colin; Galarneau, Jean-Rene; Kulkarni, Upendra; Richmond, Wendy; Bretz, Angela; Xiao, Linda; Supek, Frantisek; Wiesmann, Christian; Honnappa, Srinivas; Be, Celine; Mäser, Pascal; Kaiser, Marcel; Ritchie, Ryan; Barrett, Michael P; Diagana, Thierry T; Sarko, Christopher; Rao, Srinivasa P S