日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice

突变朊病毒蛋白增强NMDA受体活性,激活蛋白激酶C (PKC),并在小鼠中引发快速兴奋性毒性。

Lin, Joie; Callender, Julia A; Mayfield, Joshua E; McClatchy, Daniel B; Ojeda-Juárez, Daniel; Pourhamzeh, Mahsa; Soldau, Katrin; Kurt, Timothy D; Danque, Garrett A; Khuu, Helen; Ronson, Josephina E; Pizzo, Donald P; Du, Yixing; Gruber, Maxwell A; Sevillano, Alejandro M; Wang, Jin; Orrú, Christina D; Chen, Joy; Funk, Gail; Aguilar-Calvo, Patricia; Aulston, Brent D; Roy, Subhojit; Rho, Jong M; Bui, Jack D; Newton, Alexandra C; Lipton, Stuart A; Caughey, Byron; Patrick, Gentry N; Doré, Kim; Yates, John R 3rd; Sigurdson, Christina J

Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders.

对突触进行综合多组学表征,揭示了与神经发育障碍相关的 RNA 加工因子和泛素连接酶

Mei Yuan, Gosztyla Maya L, Tan Xinzhu, Dozier Lara E, Wilkinson Brent, McKetney Justin, Lee John, Chen Michael, Tsai Dorothy, Kopalle Hema, Gritsenko Marina A, Hartel Nicolas, Graham Nicholas A, Flores Ilse, Gilmore-Hall Stephen K, Xu Shuhao, Marquez Charlotte A, Liu Sophie N, Fong Dylan, Chen Jing, Licon Kate, Hong Derek, Wright Sarah N, Kreisberg Jason F, Nott Alexi, Smith Richard D, Qian Wei-Jun, Swaney Danielle L, Iakoucheva Lilia M, Krogan Nevan J, Patrick Gentry N, Zhou Yang, Feng Guoping, Coba Marcelo P, Yeo Gene W, Ideker Trey

Nootropic benzothiazoles promote dendritic spine formation by targeting fascin-1

促智苯并噻唑类药物通过靶向fascin-1促进树突棘形成。

Shivkumar, Aashish; Berg, Kyle R; Sibucao, Kevin C; Leriche, Geoffray; Dozier, Lara E; Espinoza, Carla A; Patrick, Gentry N; Gaieb, Zied; Seitz, Christian; Amaro, Rommie E; Park, Hyun-Hee; Hoe, Hyang-Sook; Wozniak, Jacob; Gonzalez, David J; Sinha, Saptarshi; Ghosh, Pradipta; Yang, Jerry

Inherently Emissive Puromycin Analogues for Live Cell Labelling

用于活细胞标记的固有发光嘌呤霉素类似物

Hadidi, Kaivin; Steinbuch, Kfir B; Dozier, Lara E; Patrick, Gentry N; Tor, Yitzhak

Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain

胍基化新霉素偶联物可增强鼻内酶替代疗法在大脑中的疗效

Tong, Wenyong; Dwyer, Chrissa A; Thacker, Bryan E; Glass, Charles A; Brown, Jillian R; Hamill, Kristina; Moremen, Kelley W; Sarrazin, Stéphane; Gordts, Philip L S M; Dozier, Lara E; Patrick, Gentry N; Tor, Yitzhak; Esko, Jeffrey D

Activity-dependent growth of new dendritic spines is regulated by the proteasome

蛋白酶体调控着依赖于细胞活动的新树突棘生长。

Hamilton, Andrew M; Oh, Won Chan; Vega-Ramirez, Hugo; Stein, Ivar S; Hell, Johannes W; Patrick, Gentry N; Zito, Karen

Ubiquitin-dependent endocytosis, trafficking and turnover of neuronal membrane proteins

泛素依赖性内吞作用、神经元膜蛋白的运输和周转

Schwarz, Lindsay A; Patrick, Gentry N

Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway.

GluA1 的活性依赖性泛素化介导了一种独特的 AMPA 受体内吞和分选途径

Schwarz Lindsay A, Hall Benjamin J, Patrick Gentry N

Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures

缺乏双皮质素和双皮质素样激酶2的小鼠表现出海马神经元成熟异常和自发性癫痫发作。

Kerjan, Géraldine; Koizumi, Hiroyuki; Han, Edward B; Dubé, Celine M; Djakovic, Stevan N; Patrick, Gentry N; Baram, Tallie Z; Heinemann, Stephen F; Gleeson, Joseph G