Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence
使用小分子抑制剂 FQI1 或 siRNA 靶向致癌基因 LSF 会导致有丝分裂延迟和染色体未对齐，从而导致细胞死亡或衰老
期刊:BMC Cancer
影响因子:3.4
doi:10.1186/s12885-020-07039-1
Jennifer L S Willoughby, Kelly George, Mark P Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E Schaus, Kevin Fitzgerald, Jagesh Shah, Ulla Hansen
信号转导
细胞生物学
肿瘤
其它细胞
Senescence
