日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.

第三代 AKR1C3 激活的前药 ACHM-025 可根除侵袭性 T 细胞急性淋巴细胞白血病的临床前模型中的疾病

Toscan Cara E, McCalmont Hannah, Ashoorzadeh Amir, Lin Xiaojing, Fu Zhe, Doculara Louise, Kosasih Hansen J, Cadiz Roxanne, Zhou Anthony, Williams Sarah, Evans Kathryn, Khalili Faezeh, Cai Ruilin, Yeats Kristy L, Gifford Andrew J, Pickford Russell, Mayoh Chelsea, Xie Jinhan, Henderson Michelle J, Trahair Toby N, Patterson Adam V, Smaill Jeff B, de Bock Charles E, Lock Richard B

Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?

靶向肿瘤的细菌作为免疫刺激剂——癌症免疫疗法的未来?

Mowday, Alexandra M; van de Laak, Jella M; Fu, Zhe; Henare, Kimiora L; Dubois, Ludwig; Lambin, Philippe; Theys, Jan; Patterson, Adam V

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

对一种经工程改造以提高5-硝基咪唑PET探针SN33623活化能力的硝基还原酶进行结构评估

Sharrock, Abigail V; Mumm, Jeff S; Williams, Elsie M; Čėnas, Narimantas; Smaill, Jeff B; Patterson, Adam V; Ackerley, David F; Bagdžiūnas, Gintautas; Arcus, Vickery L

Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery

梭菌:利用肿瘤坏死进行靶向基因递送

Theys, Jan; Patterson, Adam V; Mowday, Alexandra M

Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506

哌嗪基硝基苯甲酰胺缺氧/GDEPT前药的设计与生物学评价:CP-506的发现

Ashoorzadeh, Amir; Mowday, Alexandra M; Abbattista, Maria R; Guise, Christopher P; Bull, Matthew R; Silva, Shevan; Patterson, Adam V; Smaill, Jeff B

Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

对用于癌症基因治疗的亲脂性硝基芳香族前药系列进行构效关系研究

Ashoorzadeh, Amir; Mowday, Alexandra M; Guise, Christopher P; Silva, Shevan; Bull, Matthew R; Abbattista, Maria R; Copp, Janine N; Williams, Elsie M; Ackerley, David F; Patterson, Adam V; Smaill, Jeff B

Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

肿瘤乏氧介导的免疫抑制:改善癌症免疫治疗的机制和治疗方法

Fu, Zhe; Mowday, Alexandra M; Smaill, Jeff B; Hermans, Ian F; Patterson, Adam V

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

通过开发一种对人醛酮还原酶1C3有氧代谢具有抗性的类似物,恢复生物还原前药PR-104的肿瘤选择性

Abbattista, Maria R; Ashoorzadeh, Amir; Guise, Christopher P; Mowday, Alexandra M; Mittra, Rituparna; Silva, Shevan; Hicks, Kevin O; Bull, Matthew R; Jackson-Patel, Victoria; Lin, Xiaojing; Prosser, Gareth A; Lambie, Neil K; Dachs, Gabi U; Ackerley, David F; Smaill, Jeff B; Patterson, Adam V

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents

安托芬和泰洛福林前药作为缺氧靶向抗癌药物的设计、合成及体外生物学评价

Omran, Ziad; Guise, Chris P; Chen, Linwei; Rauch, Cyril; Abdalla, Ashraf N; Abdullah, Omeima; Sindi, Ikhlas A; Fischer, Peter M; Smaill, Jeff B; Patterson, Adam V; Liu, Yuxiu; Wang, Qingmin

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

替拉帕明还原的亚细胞定位显著影响有氧细胞毒性,但不影响缺氧细胞毒性

Guise, Chris P; Abbattista, Maria R; Anderson, Robert F; Li, Dan; Taghipouran, Rana; Tsai, Angela; Lee, Su Jung; Smaill, Jeff B; Denny, William A; Hay, Michael P; Wilson, William R; Hicks, Kevin O; Patterson, Adam V