日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clinical immunogenicity outcomes from GENEr8-1, a phase 3 study of valoctocogene roxaparvovec, an AAV5-vectored gene therapy for hemophilia A

GENEr8-1 是一项针对血友病 A 的 AAV5 载体基因疗法 valoctocogene roxaparvovec 的 3 期研究,该研究评估了其临床免疫原性结果。

Long, Brian R; Robinson, Tara M; Day, Jonathan R S; Yu, Hua; Lau, Kelly; Imtiaz, Urooj; Patton, Kathryn S; de Hart, Greg; Henshaw, Joshua; Agarwal, Suresh; Vettermann, Christian; Zoog, Stephen J; Gupta, Soumi

Ultra-sensitive AAV capsid detection by immunocapture-based qPCR following factor VIII gene transfer

利用基于免疫捕获的qPCR技术,在VIII因子基因转移后进行超灵敏的AAV衣壳检测

Sandza, Krystal; Clark, Annie; Koziol, Elli; Akeefe, Hassibullah; Yang, Fan; Holcomb, Jennifer; Patton, Kathryn; Hammon, Kevin; Mitchell, Nina; Wong, Wing Y; Zoog, Stephen J; Kim, Benjamin; Henshaw, Joshua; Vettermann, Christian

Monitoring cell-mediated immune responses in AAV gene therapy clinical trials using a validated IFN-γ ELISpot method

利用经验证的IFN-γ ELISpot方法监测AAV基因治疗临床试验中的细胞介导免疫反应

Patton, Kathryn S; Harrison, M Travis; Long, Brian R; Lau, Kelly; Holcomb, Jennifer; Owen, Rachel; Kasprzyk, Theresa; Janetzki, Sylvia; Zoog, Stephen J; Vettermann, Christian

Comprehensive genetic testing identifies targetable genomic alterations in most patients with non-small cell lung cancer, specifically adenocarcinoma, single institute investigation

全面的基因检测可以识别出大多数非小细胞肺癌患者(特别是腺癌患者)体内可靶向的基因组改变,这是一项单中心研究的结果。

Vigneswaran, Janani; Tan, Yi-Hung Carol; Murgu, Septimiu D; Won, Brian M; Patton, Kathryn Alexa; Villaflor, Victoria M; Hoffman, Philip C; Hensing, Thomas; Hogarth, D Kyle; Malik, Renuka; MacMahon, Heber; Mueller, Jeffrey; Simon, Cassie A; Vigneswaran, Wickii T; Wigfield, Christopher H; Ferguson, Mark K; Husain, Aliya N; Vokes, Everett E; Salgia, Ravi

An adjuvanted respiratory syncytial virus fusion protein induces protection in aged BALB/c mice

一种佐剂化的呼吸道合胞病毒融合蛋白可诱导老年BALB/c小鼠产生保护作用。

Cherukuri, Anu; Stokes, Kate L; Patton, Kathryn; Kuo, Howard; Sakamoto, Kaori; Lambert, Stacie; Stillman, Elizabeth; Moore, Martin L; Lee, Sujin

Encapsulating immunostimulatory CpG oligonucleotides in listeriolysin O-liposomes promotes a Th1-type response and CTL activity.

将免疫刺激性 CpG 寡核苷酸封装在李斯特菌溶血素 O 脂质体中可促进 Th1 型反应和 CTL 活性

Andrews Chasity D, Huh Myung-Sook, Patton Kathryn, Higgins Debbie, Van Nest Gary, Ott Gary, Lee Kyung-Dall