日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma

RIT1驱动癌基因转化,是肺腺癌的可靶向治疗靶点

Alessandro M Mozzarelli,Antonio Cuevas-Navarro,Emily G Shuldiner,Martha Vega,Walid K Chatila,Jierui Xu,Henry S Walch,Yuzhe Niu,Dmitri A Petrov,Nikolaus Schultz,Anatoly Urisman,Charles M Rudin,Monte M Winslow,Pau Castel

Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

SMYD2 对染色质修饰因子 KMT2D 的甲基化作用有助于激素依赖性乳腺癌的治疗反应。

Ryan Blawski ,Bujamin H Vokshi ,Xinyu Guo ,Srushti Kittane ,Mirna Sallaku ,Wanlu Chen ,Martina Gjyzari ,Tony Cheung ,Yuhan Zhang ,Christopher Simpkins ,Weiqiang Zhou ,Amanda Kulick ,Peihua Zhao ,Meihan Wei ,Pranavkrishna Shivashankar ,Tatiana Prioleau ,Pedram Razavi ,Richard Koche ,Vito W Rebecca ,Elisa de Stanchina ,Pau Castel ,Ho Man Chan ,Maurizio Scaltriti ,Emiliano Cocco ,Hongkai Ji ,Minkui Luo ,Eneda Toska

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy

致病性RIT1介导的RAS依赖性RAF-MAPK过度激活是Noonan综合征相关心脏肥大的治疗靶点。

Antonio Cuevas-Navarro ,Morgan Wagner ,Richard Van ,Monalisa Swain ,Stephanie Mo ,John Columbus ,Madeline R Allison ,Alice Cheng ,Simon Messing ,Thomas J Turbyville ,Dhirendra K Simanshu ,Matthew J Sale ,Frank McCormick ,Andrew G Stephen ,Pau Castel

The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling

核糖体S6激酶2 (RSK2)-SPRED2复合物调节RSK底物的磷酸化和MAPK信号传导

Jocelyne Lopez ,Daniel A Bonsor ,Matthew J Sale ,Anatoly Urisman ,Jennifer L Mehalko ,Miranda Cabanski-Dunning ,Pau Castel ,Dhirendra K Simanshu ,Frank McCormick

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

非经典RAS蛋白水解受损驱动克隆性造血转化

Sisi Chen # ,Rahul S Vedula # ,Antonio Cuevas-Navarro # ,Bin Lu ,Simon J Hogg ,Eric Wang ,Salima Benbarche ,Katherine Knorr ,Won Jun Kim ,Robert F Stanley ,Hana Cho ,Caroline Erickson ,Michael Singer ,Dan Cui ,Steven Tittley ,Benjamin H Durham ,Tatiana S Pavletich ,Elise Fiala ,Michael F Walsh ,Daichi Inoue ,Sebastien Monette ,Justin Taylor ,Neal Rosen ,Frank McCormick ,R Coleman Lindsley ,Pau Castel ,Omar Abdel-Wahab

Angiocrine polyamine production regulates adiposity

血管分泌多胺的产生调节肥胖

Erika Monelli, Pilar Villacampa, Amaia Zabala-Letona, Anabel Martinez-Romero, Judith Llena, Daniel Beiroa, Leonor Gouveia, Iñigo Chivite, Sebastián Zagmutt, Pau Gama-Perez, Oscar Osorio-Conles, Laia Muixi, Ainara Martinez-Gonzalez, Sandra D Castillo, Natalia Martín-Martín, Pau Castel, Lorea Valcarce

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

致癌 PI3K 诱导的转录组图揭示了剪接和基因表达调控中的关键功能

Erik Ladewig #, Flavia Michelini #, Komal Jhaveri #, Pau Castel, Javier Carmona, Lauren Fairchild, Adler G Zuniga, Amaia Arruabarrena-Aristorena, Emiliano Cocco, Ryan Blawski, Srushti Kittane, Yuhan Zhang, Mirna Sallaku, Laura Baldino, Vasilis Hristidis, Sarat Chandarlapaty, Omar Abdel-Wahab, Christ

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

LZTR1 功能丧失突变体的跨物种分析表明其对 RIT1 直系同源物的依赖性

Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz, Joaquim Grego-Bessa, Alice Cheng, Katherine A Rauen, Anatoly Urisman, Frank McCormick, Gerardo Jimenez, Pau Castel

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

次要内含子保留驱动克隆性造血疾病和多种癌症易感性

Daichi Inoue # ,Jacob T Polaski # ,Justin Taylor # ,Pau Castel ,Sisi Chen ,Susumu Kobayashi ,Simon J Hogg ,Yasutaka Hayashi ,Jose Mario Bello Pineda ,Ettaib El Marabti ,Caroline Erickson ,Katherine Knorr ,Miki Fukumoto ,Hiromi Yamazaki ,Atsushi Tanaka ,Chie Fukui ,Sydney X Lu ,Benjamin H Durham ,Bo Liu ,Eric Wang ,Sanjoy Mehta ,Daniel Zakheim ,Ralph Garippa ,Alex Penson ,Guo-Liang Chew ,Frank McCormick ,Robert K Bradley ,Omar Abdel-Wahab

Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors

PIK3CA 突变乳腺癌中的基因组改变导致 mTORC1 激活并限制对 PI3Kα 抑制剂的敏感性

Yanyan Cai #, Guotai Xu #, Fan Wu, Flavia Michelini, Carmen Chan, Xuan Qu, Pier Selenica, Erik Ladewig, Pau Castel, Yuanming Cheng, Alison Zhao, Komal Jhaveri, Eneda Toska, Marta Jimenez, Alexandra Jacquet, Alicia Tran-Dien, Fabrice Andre, Sarat Chandarlapaty, Jorge S Reis-Filho, Pedram Razavi, Maur