日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Retrospective analysis of cutaneous immune-related adverse events following checkpoint inhibitor therapy in melanoma patients reveals increased risk associated with the HLA-B*51:01 allele

对黑色素瘤患者接受免疫检查点抑制剂治疗后发生的皮肤免疫相关不良事件进行回顾性分析发现,HLA-B*51:01等位基因与风险增加相关。

DiLeo, Mckenzie; Oglesby, Samantha; Leung, Cheuk Hong; Pauken, Kristen E; Farooq, Sahira; Haydu, Lauren E; Kubicki, Shelby L; Martinez, Rebeca; Welborn, Macartney; Zahiruddin, Sana; Zou, Jun; Cao, Kai; Patel, Anisha B

Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord

移植的脊髓神经元与受损脊髓后肢运动回路的功能性突触连接

Ashley Tucker ,Angelina Baltazar # ,Jaclyn T Eisdorfer # ,Joshua K Thackray # ,Katie Vo # ,Hannah Thomas ,Avnika Tandon ,Joshua Moses ,Brendan Singletary ,Tucker Gillespie ,Ashley Smith ,Anna Pauken ,Sneha Nadella ,Michael Pitonak ,Sunjay Letchuman ,Julius Jang ,Michael Totty ,Frank L Jalufka ,Miriam Aceves ,Andrew F Adler ,Stephen Maren ,Heath Blackmon ,Dylan A McCreedy ,Victoria Abraira ,Jennifer N Dulin

Single-Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T-cell Subpopulation That Is Correlated with Response to Checkpoint Therapy in Melanoma

单细胞分析揭示了一种功能异质性的耗竭CD8+ T细胞亚群,该亚群与黑色素瘤对免疫检查点疗法的反应相关。

Kelly M Mahuron # ,Osmaan Shahid # ,Prachi Sao # ,Clinton Wu # ,Alexandra M Haugh ,Laura A Huppert ,Lauren S Levine ,Margaret M Lowe ,Michael Alvarado ,Markee Micu ,Katy K Tsai ,Melissa Chow ,Meromit Singer ,Jason M Schenkel ,Arlene H Sharpe ,Michael D Rosenblum ,Kristen E Pauken ,Adil I Daud

PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion

PD-1以细胞内在和细胞外在两种方式调节肿瘤浸润的CD8+ T细胞。

Pauken, Kristen E; Markson, Samuel C; Conway, Thomas S; Juneja, Vikram R; Shahid, Osmaan; Burke, Kelly P; Rowe, Jared H; Nguyen, Thao H; Collier, Jenna L; Walsh, Jaclyn M L; Fung, Megan E; Luber, Jacob M; Ringel, Alison E; Schenkel, Jason M; Freeman, Gordon J; Haigis, Marcia C; Singer, Meromit; Sharpe, Arlene H

In vivo antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity

体内抗体标记途径和荧光染料决定了标记效率、灵敏度和持久性。

Hagan, Natalie B; Inaku, Charles; Kunder, Nikesh; White, Tayleur; Iraguha, Thierry; Meyer, Anna; Pauken, Kristen E; Schenkel, Jason M

Dietary methionine restriction primes T cell metabolism for activation and tumor inhibition and enhances the efficacy of immune checkpoint blockade

限制膳食蛋氨酸摄入可促进T细胞代谢,使其活化并抑制肿瘤,同时增强免疫检查点阻断疗法的疗效。

Qing, Xiaoqing; Chakraborty, Binita; Liu, Panpan; Artham, Sandeep; Juras, Patrick K; Guan, Dongyin; Pauken, Kristen E; Chang, Ching-Yi; Gao, Xia

Bhlhe40 Coordinates T Cell Programs with Distinct CD4 and CD8 T Cell Requirements for Anti-PD-1 Versus Anti-CTLA-4.

Bhlhe40 协调 T 细胞程序,对 CD4 和 CD8 T 细胞有不同的抗 PD-1 与抗 CTLA-4 需求。

Saha Akata, Minowa Tomoyuki, Shavkunov Alexander S, Salmon Avery J, Keshari Sunita, Jarjour Nicholas N, Pauken Kristen E, Hu Kenneth H, Edelson Brian T, Chen Ken, Gubin Matthew M

Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy

比较新抗原癌症疫苗和免疫检查点疗法,揭示了一种有效的疫苗和抗TREM2巨噬细胞靶向双重疗法。

Sunita Keshari ,Alexander S Shavkunov ,Qi Miao ,Akata Saha ,Tomoyuki Minowa ,Martina Molgora ,Charmelle D Williams ,Mehdi Chaib ,Anna M Highsmith ,Josué E Pineda ,Sayan Alekseev ,Elise Alspach ,Kenneth H Hu ,Marco Colonna ,Kristen E Pauken ,Ken Chen ,Matthew M Gubin

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts' blood cells in space

转录组学分析揭示了宇航员太空血细胞中线粒体功能障碍和T细胞耗竭的潜在机制

Moreno-Villanueva, Maria; Jimenez-Chavez, Luis E; Krieger, Stephanie; Ding, Liang-Hao; Zhang, Ye; Babiak-Vazquez, Adriana; Berres, Mark; Splinter, Sandra; Pauken, Kristen E; Schaefer, Brian C; Crucian, Brian E; Wu, Honglu

Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer.

纵向血管内抗体标记法确定调节性 T 细胞募集是肺癌小鼠模型中的治疗靶点

Shanahan Sean-Luc, Kunder Nikesh, Inaku Charles, Hagan Natalie B, Gibbons Grace, Mathey-Andrews Nicolas, Anandappa Gayathri, Soares Shawn, Pauken Kristen E, Jacks Tyler, Schenkel Jason M