日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

IPF 成纤维细胞灶的转录组分析确定了参与纤维形成的关键途径

Delphine Guillotin #, Adam R Taylor #, Manuela Platé #, Paul F Mercer, Lindsay M Edwards, Ross Haggart, Gino Miele, Robin J McAnulty, Toby M Maher, Robert E Hynds, Mariam Jamal-Hanjani, Richard P Marshall, Andrew J Fisher, Andy D Blanchard #, Rachel C Chambers #

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

吸入性小分子 αvβ6 整合素抑制剂治疗特发性肺纤维化的转化药理学

Alison E John, Rebecca H Graves, K Tao Pun, Giovanni Vitulli, Ellen J Forty, Paul F Mercer, Josie L Morrell, John W Barrett, Rebecca F Rogers, Maryam Hafeji, Lloyd I Bibby, Elaine Gower, Valerie S Morrison, Yim Man, James A Roper, Jeni C Luckett, Lee A Borthwick, Ben S Barksby, Rachel A Burgoyne, Ro

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis

mTORC1 扩增 ATF4 依赖的从头丝氨酸-甘氨酸途径,在 TGF-β1 诱导的胶原生物合成过程中提供甘氨酸

Brintha Selvarajah, Ilan Azuelos, Manuela Platé, Delphine Guillotin, Ellen J Forty, Greg Contento, Hannah V Woodcock, Matthew Redding, Adam Taylor, Gino Brunori, Pascal F Durrenberger, Riccardo Ronzoni, Andy D Blanchard, Paul F Mercer, Dimitrios Anastasiou, Rachel C Chambers

Evidence for chemokine synergy during neutrophil migration in ARDS

ARDS 中性粒细胞迁移过程中趋化因子协同作用的证据

Andrew E Williams, Ricardo J José, Paul F Mercer, David Brealey, Dhruv Parekh, David R Thickett, Cecelia O'Kane, Danny F McAuley, Rachel C Chambers

Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection

蛋白酶激活受体 1 在细菌性肺部感染过程中对中性粒细胞炎症的调节

Ricardo J José, Andrew E Williams, Paul F Mercer, Michal G Sulikowski, Jeremy S Brown, Rachel C Chambers

Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis

肺上皮是肺纤维化中蛋白酶激活受体 1 诱导 CCL2 的主要来源

Paul F Mercer, Robin H Johns, Chris J Scotton, Malvina A Krupiczojc, Melanie Königshoff, David C J Howell, Robin J McAnulty, Anuk Das, Andrew J Thorley, Terry D Tetley, Oliver Eickelberg, Rachel C Chambers

Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways

凝血酶通过 PAR1 与 Galphaq 的偶联以及 ERK1/2 与 Rho 激酶信号通路的协同作用诱导成纤维细胞 CCL2/JE 的产生和释放

Xiaoling Deng, Paul F Mercer, Chris J Scotton, Annette Gilchrist, Rachel C Chambers