日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hypoxia-Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment-Resistant Cancer Cells

ATR 抑制剂 AZD6738 的缺氧反应性前药可选择性地消灭耐药癌细胞

Francis M Barnieh, Goreti Ribeiro Morais, Paul M Loadman, Robert A Falconer, Sherif F El-Khamisy

Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues

CD13 的癌症特异性糖基化影响其在临床前癌症组织中的检测和活性

Francis M Barnieh, Sebastian P Galuska, Paul M Loadman, Simon Ward, Robert A Falconer, Sherif F El-Khamisy

Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

肿瘤靶向多卡米星药物的细胞色素 P450 结合和生物活化

Aaron G Bart, Goreti Morais, Venu R Vangala, Paul M Loadman, Klaus Pors, Emily E Scott

Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

环氧合酶活性介导结直肠癌细胞对 omega-3 多不饱和脂肪酸二十碳五烯酸的抗性

Milene Volpato, Nicola Ingram, Sarah L Perry, Jade Spencer, Amanda D Race, Catriona Marshall, John M Hutchinson, Anna Nicolaou, Paul M Loadman, P Louise Coletta, Mark A Hull

Theranostic nanoparticles enhance the response of glioblastomas to radiation

诊疗纳米粒子增强胶质母细胞瘤对放射的反应

Wei Wu, Jessica L Klockow, Suchismita Mohanty, Kimberly S Ku, Maryam Aghighi, Stavros Melemenidis, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Ning Zhao, Jürgen Schlegel, Edward E Graves, Jianghong Rao, Paul M Loadman, Robert A Falconer, Sudip Mukherjee, Frederick T Chin, Heike E Daldrup-Link

A Novel Theranostic Strategy for MMP-14-Expressing Glioblastomas Impacts Survival

MMP-14 表达胶质母细胞瘤的新型治疗诊断策略影响生存

Suchismita Mohanty, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Jessica Klockow, Ketan Yerneni, Laura Pisani, Frederick T Chin, Siddharta Mitra, Samuel Cheshier, Edwin Chang, Sanjiv Sam Gambhir, Jianghong Rao, Paul M Loadman, Robert A Falconer, Heike E Daldrup-Link

Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass

与胃绕道手术不同,袖状胃切除术后 6 个月,结直肠癌风险的粘膜生物标志物不会增加

Prashant Kant, Sarah L Perry, Simon P Dexter, Amanda D Race, Paul M Loadman, Mark A Hull

Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration

药理学抑制聚唾液酸转移酶 ST8SiaII 调节肿瘤细胞迁移

Yousef M J Al-Saraireh, Mark Sutherland, Bradley R Springett, Friedrich Freiberger, Goreti Ribeiro Morais, Paul M Loadman, Rachel J Errington, Paul J Smith, Minoru Fukuda, Rita Gerardy-Schahn, Laurence H Patterson, Steven D Shnyder, Robert A Falconer

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

FGFR1 通过 MAPK/PLCγ/COX-2 介导的机制诱导上皮细胞向间质细胞转化

Darren C Tomlinson, Euan W Baxter, Paul M Loadman, Mark A Hull, Margaret A Knowles

MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas

MMP-10 过度表达,具有蛋白水解活性,是人类肺癌治疗干预的潜在靶点

Jason H Gill, Ian G Kirwan, Jill M Seargent, Sandie W Martin, Sidiq Tijani, Vladimir A Anikin, Alan J Mearns, Michael C Bibby, Alan Anthoney, Paul M Loadman