日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery of N-Acetyltransferase 8-Like (NAT8L) inhibitors based on a N-Acylated (Piperidin-3-ylmethyl)-1,2,4-Oxadiazole Scaffold

基于 N-酰化（哌啶-3-基甲基）-1,2,4-恶二唑骨架的 N-乙酰转移酶 8 样（NAT8L）抑制剂的发现

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00623
Nayeen, Md Junayed; Thomas, Ajit G; Kundu, Biswajit; Carlyle, Evan; Hin, Niyada; Hin, Philana; Pal, Arindom; Paule, James; Rais, Rana; Slusher, Barbara S; Tsukamoto, Takashi
发表日期：2026
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Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics

用1,2,3-三唑类化合物生物等排取代酰胺类化合物可改善多巴胺D4受体配体的药代动力学

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00646
Alkhatib, Mohammad; Jakobs, Franziska M; Hanson, John N; Nilson, Ashley N; Moritz, Amy E; Li, Tian; Faibille, Afua B; Bourn, Lindsay A; Ramdhan, Peter A; Ricchezza, Joseph 4th; Jordan, Shannon; Panasis, Diandra; Nguyen, Norman; Kasarla, Nitish; Wang, Bryant; Garcia, Sergio Sola; Saez, Julianna; Paule, James; Lee, Chae Bin; Rais, Rana; Slusher, Barbara S; Sibley, David R; Li, Chenglong; Keck, Thomas M; Boateng, Comfort A
信号转导
发表日期：2026
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Exploring the antimicrobial activity of pantothenamides against uropathogenic Escherichia coli.

探索泛酰胺对泌尿道致病性大肠杆菌的抗菌活性

期刊:Microbiology Spectrum
影响因子:3.8
doi:10.1128/spectrum.03069-24
DeColli Alicia A, Meyers David J, Ranjit Arina, Paule James, Serrano-Diaz Erika, Bockley Kimberly M, Ensign Laura M, Rais Rana, Freel Meyers Caren L
微生物学
发表日期：2025
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Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

对 1-(4-(2-双(4-氟苯基)甲基)亚磺酰基)烷基脂环胺进行修饰，以提高其代谢稳定性并保持非典型 DAT 抑制剂特性

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.3c02037
Okorom, Amarachi V; Camacho-Hernandez, Gisela Andrea; Salomon, Kristine; Lee, Kuo Hao; Ku, Therese C; Cao, Jianjing; Won, Sung Joon; Friedman, Jacob; Lam, Jenny; Paule, James; Rais, Rana; Klein, Benjamin; Xi, Zheng-Xiong; Shi, Lei; Loland, Claus J; Newman, Amy Hauck
代谢
发表日期：2024
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Podocalyxin promotes an impermeable epithelium and inhibits pro-implantation factors to negatively regulate endometrial receptivity

足细胞萼蛋白促进上皮细胞不通透，抑制促植入因子，从而对子宫内膜容受性产生负面调节作用

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-021-03425-2
Sophea Heng, Nirukshi Samarajeewa, Yao Wang, Sarah G Paule, James Breen, Guiying Nie
细胞生物学
上皮细胞
FCM
IF
IHC-P
WB
发表日期：2021
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