日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions

典型的转录模块是酵母基因调控响应生长条件变化的基础。

Talavera, David; Kershaw, Christopher J; Costello, Joseph L; Castelli, Lydia M; Rowe, William; Sims, Paul F G; Ashe, Mark P; Grant, Chris M; Pavitt, Graham D; Hubbard, Simon J

Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

通过解离 eIF2α 磷酸化三元复合物实现翻译起始的故障安全控制

Jennings, Martin D; Kershaw, Christopher J; Adomavicius, Tomas; Pavitt, Graham D

The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response

酵母La相关蛋白Slf1p是氧化应激反应过程中翻译的关键激活因子

Kershaw, Christopher J; Costello, Joseph L; Castelli, Lydia M; Talavera, David; Rowe, William; Sims, Paul F G; Ashe, Mark P; Hubbard, Simon J; Pavitt, Graham D; Grant, Chris M

A new function and complexity for protein translation initiation factor eIF2B

蛋白质翻译起始因子eIF2B的新功能和复杂性

Jennings, Martin D; Pavitt, Graham D

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

eIF2B促进eIF5与eIF2*GDP解离,从而促进鸟嘌呤核苷酸交换,启动翻译。

Jennings, Martin D; Zhou, Yu; Mohammad-Qureshi, Sarah S; Bennett, David; Pavitt, Graham D

Less translational control, more memory

翻译控制减少,记忆增强

Pavitt, Graham D

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body

杂醇油通过抑制eIF2B来调节翻译起始,从而减少三元复合物的形成,其机制可能涉及改变eIF2B复合物的完整性和动态性。

Taylor, Eleanor J; Campbell, Susan G; Griffiths, Christian D; Reid, Peter J; Slaven, John W; Harrison, Richard J; Sims, Paul F G; Pavitt, Graham D; Delneri, Daniela; Ashe, Mark P

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.

真核起始因子 2B (eIF2B) 催化结构域与 eIF2β 和 -2γ 之间的关键接触介导鸟嘌呤核苷酸交换

Mohammad-Qureshi Sarah S, Haddad Raphaël, Hemingway Elizabeth J, Richardson Jonathan P, Pavitt Graham D

An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation

eIF5/eIF2复合物在翻译起始过程中拮抗eIF2B介导的鸟嘌呤核苷酸交换。

Singh, Chingakham Ranjit; Lee, Bumjun; Udagawa, Tsuyoshi; Mohammad-Qureshi, Sarah S; Yamamoto, Yasufumi; Pavitt, Graham D; Asano, Katsura

Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways

全球基因表达谱分析揭示了针对不同真核翻译起始因子2B靶向应激通路的广泛而独特的翻译反应

Smirnova, Julia B; Selley, Julian N; Sanchez-Cabo, Fatima; Carroll, Kathleen; Eddy, A Alan; McCarthy, John E G; Hubbard, Simon J; Pavitt, Graham D; Grant, Chris M; Ashe, Mark P