Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
C9orf72-ALS iPSC 衍生的小胶质细胞中自噬破坏导致细胞自主免疫功能障碍,从而导致神经退行性病变
期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.abq0651
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran