日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα

细胞死亡受到抑制:线粒体与IκBα之间意想不到的联系

Pazarentzos, Evangelos

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers

代谢调节剂 PDHK1 在 PTEN 缺陷细胞和癌症中的合成必要性

Nilanjana Chatterjee, Evangelos Pazarentzos, Manasi K Mayekar, Philippe Gui, David V Allegakoen, Gorjan Hrustanovic, Victor Olivas, Luping Lin, Erik Verschueren, Jeffrey R Johnson, Matan Hofree, Jenny J Yan, Billy W Newton, John V Dollen, Charles H Earnshaw, Jennifer Flanagan, Elton Chan, Saurabh As

Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution

预测多药治疗转换策略以克服肿瘤异质性和进化的新型计算方法

Vanessa D Jonsson, Collin M Blakely, Luping Lin, Saurabh Asthana, Nikolai Matni, Victor Olivas, Evangelos Pazarentzos, Matthew A Gubens, Boris C Bastian, Barry S Taylor, John C Doyle, Trever G Bivona

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer

RAS-MAPK 依赖性为 EML4-ALK 阳性肺癌的合理联合治疗策略奠定基础

Gorjan Hrustanovic, Victor Olivas, Evangelos Pazarentzos, Asmin Tulpule, Saurabh Asthana, Collin M Blakely, Ross A Okimoto, Luping Lin, Dana S Neel, Amit Sabnis, Jennifer Flanagan, Elton Chan, Marileila Varella-Garcia, Dara L Aisner, Aria Vaishnavi, Sai-Hong I Ou, Eric A Collisson, Eiki Ichihara, Ph

AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas

AXL 通过激活头颈部和食管鳞状细胞癌中的 EGFR/PKC/mTOR 轴来介导对 PI3Kα 抑制的抵抗

Moshe Elkabets, Evangelos Pazarentzos, Dejan Juric, Qing Sheng, Raphael A Pelossof, Samuel Brook, Ana Oaknin Benzaken, Jordi Rodon, Natasha Morse, Jenny Jiacheng Yan, Manway Liu, Rita Das, Yan Chen, Angela Tam, Huiqin Wang, Jinsheng Liang, Joseph M Gurski, Darcy A Kerr, Rafael Rosell, Cristina Teixi

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

Hippo 效应分子 YAP 促进对 RAF 和 MEK 靶向癌症疗法的耐药性

Luping Lin, Amit J Sabnis, Elton Chan, Victor Olivas, Lindsay Cade, Evangelos Pazarentzos, Saurabh Asthana, Dana Neel, Jenny Jiacheng Yan, Xinyuan Lu, Luu Pham, Mingxue M Wang, Niki Karachaliou, Maria Gonzalez Cao, Jose Luis Manzano, Jose Luis Ramirez, Jose Miguel Sanchez Torres, Fiamma Buttitta, Ch

Stefan Grimm, 1963-2014, a tragic loss for the scientific community

斯特凡·格里姆(1963-2014),科学界的巨大损失。

Mahul-Mellier, A-L; Huc, L; Lemarié, A; Irshad, S; Hwang, M; Datler, C; Pazarentzos, E

NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer

NF-κB 活化复合物参与 EGFR 致癌基因抑制,促进肺癌肿瘤细胞存活和残留疾病

Collin M Blakely, Evangelos Pazarentzos, Victor Olivas, Saurabh Asthana, Jenny Jiacheng Yan, Irena Tan, Gorjan Hrustanovic, Elton Chan, Luping Lin, Dana S Neel, William Newton, Kathryn L Bobb, Timothy R Fouts, Jeffrey Meshulam, Matthew A Gubens, David M Jablons, Jeffrey R Johnson, Sourav Bandyopadhy

The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis

抗癌基因 ORCTL3 靶向硬脂酰辅酶 A 去饱和酶-1,实现肿瘤特异性凋亡

G AbuAli, W Chaisaklert, E Stelloo, E Pazarentzos, M-S Hwang, D Qize, S V Harding, A Al-Rubaish, A J Alzahrani, A Al-Ali, T A B Sanders, E O Aboagye, S Grimm

Mitochondrial Ca(2+) influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction

线粒体 Ca(2+) 内流靶向心磷脂,分解呼吸链复合物 II,诱导细胞死亡

M-S Hwang, C T Schwall, E Pazarentzos, C Datler, N N Alder, S Grimm