日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Development and validation of blood-based diagnostic biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch(®) 3-dimensional genomic regulatory immuno-genetic profiling

利用 EpiSwitch® 三维基因组调控免疫遗传分析技术开发和验证肌痛性脑脊髓炎/慢性疲劳综合征 (ME/CFS) 的血液诊断生物标志物

期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-025-07203-w
Hunter, Ewan; Alshaker, Heba; Bundock, Oliver; Weston, Cicely; Bautista, Shekinah; Gebregzabhar, Abel; Virdi, Anya; Croxford, Joseph; Dring, Ann; Powell, Ryan; Vugrinec, Dominik; Kingdon, Caroline; Wilson, Carol; Dowrick, Sarah; Green, Jayne; Akoulitchev, Alexandre; Pchejetski, Dmitri
信号转导
神经科学
免疫/内分泌
发表日期：2025
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A New Blood-Based Epigenetic Diagnostic Biomarker Test (EpiSwitch(®®) NST) with High Sensitivity and Positive Predictive Value for Colorectal Cancer and Precancerous Polyps

一种新型的基于血液的表观遗传诊断生物标志物检测（EpiSwitch® NST），对结直肠癌和癌前息肉具有高灵敏度和阳性预测值

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers17030521
Hunter, Ewan; Alshaker, Heba; Weston, Cicely; Issa, Mutaz; Bautista, Shekinah; Gebregzabhar, Abel; Virdi, Anya; Dring, Ann; Powell, Ryan; Green, Jayne; Lal, Roshan; Velchuru, Vamsi; Aryal, Kamal; Bin Abu Hassan, Muhammad Radzi; Meng, Goh Tiong; Patel, Janisha Suriakant; Mohamed Gani, Shameera Pharveen; Lim, Chun Ren; Guiel, Thomas; Akoulitchev, Alexandre; Pchejetski, Dmitri
肿瘤
肠癌
表观遗传
肿瘤免疫
发表日期：2025
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Development and Validation of Blood-Based Predictive Biomarkers for Response to PD-1/PD-L1 Checkpoint Inhibitors: Evidence of a Universal Systemic Core of 3D Immunogenetic Profiling across Multiple Oncological Indications

基于血液的PD-1/PD-L1检查点抑制剂疗效预测生物标志物的开发与验证：跨多种肿瘤适应症的3D免疫遗传学分析通用系统核心的证据

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers15102696
Hunter, Ewan; Salter, Matthew; Powell, Ryan; Dring, Ann; Naithani, Tarun; Chatziioannou, Maria Eleni; Gebregzabhar, Abel; Issa, Mutaz; Green, Jayne; Ng, Serene; Lim, Chun Ren; Keat, Cheah Soon; Suan, Ang Tick; Raman, Rakesh; Fatt, Ho Kean; Luen, Fabian Lee Wei; Alshaker, Heba; Pchejetski, Dmitri; Blum, Dave; Guiel, Thomas; Heaton, Robert Jr; Levine, Jedd; Akoulitchev, Alexandre
Checkpoint
肿瘤
肿瘤免疫
PD-L1
3D/类器官
PD-1
免疫/内分泌
发表日期：2023
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Circulating Chromosome Conformation Signatures Significantly Enhance PSA Positive Predicting Value and Overall Accuracy for Prostate Cancer Detection

循环染色体构象特征显著提高PSA阳性预测值和前列腺癌检测的总体准确性

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers15030821
Pchejetski, Dmitri; Hunter, Ewan; Dezfouli, Mehrnoush; Salter, Matthew; Powell, Ryan; Green, Jayne; Naithani, Tarun; Koutsothanasi, Christina; Alshaker, Heba; Jaipuria, Jiten; Connor, Martin J; Eldred-Evans, David; Fiorentino, Francesca; Ahmed, Hashim; Akoulitchev, Alexandre; Winkler, Mathias
肿瘤
前列腺癌
肿瘤免疫
PSA
发表日期：2023
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Monocytes acquire prostate cancer specific chromatin conformations upon indirect co-culture with prostate cancer cells

单核细胞在与前列腺癌细胞间接共培养后，会获得前列腺癌特异性的染色质构象。

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2022.990842
Alshaker, Heba; Hunter, Ewan; Salter, Matthew; Ramadass, Aroul; Westra, Willem; Winkler, Mathias; Green, Jayne; Akoulitchev, Alexandre; Pchejetski, Dmitri
肿瘤
肿瘤免疫
单核细胞
细胞生物学
前列腺癌
发表日期：2022
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Chromatin conformation changes in peripheral blood can detect prostate cancer and stratify disease risk groups

外周血染色质构象变化可用于检测前列腺癌并对疾病风险群体进行分层。

期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-021-02710-y
Alshaker, Heba; Mills, Robert; Hunter, Ewan; Salter, Matthew; Ramadass, Aroul; Skinner, Benjamin Matthew; Westra, Willem; Green, Jayne; Akoulitchev, Alexandre; Winkler, Mathias; Pchejetski, Dmitri
肿瘤
前列腺癌
肿瘤免疫
发表日期：2021
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Sphingosine Kinase 1 in Breast Cancer-A New Molecular Marker and a Therapy Target

乳腺癌中的鞘氨醇激酶1——一种新的分子标志物和治疗靶点

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2020.00289
Alshaker, Heba; Thrower, Hannah; Pchejetski, Dmitri
信号转导
肿瘤
肿瘤免疫
乳腺癌
发表日期：2020
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Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting

转移性前列腺癌和乳腺癌细胞中鞘氨醇激酶敲低的转录组范围效应：对治疗靶向的影响

期刊:Frontiers in Pharmacology
影响因子:4.4
doi:10.3389/fphar.2019.00303
Heba Alshaker, Qi Wang, Daniel Brewer, Dmitri Pchejetski
免疫
细胞生物学
乳腺癌
前列腺癌
肿瘤细胞
发表日期：2019
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Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors

基于场模板的新型鞘氨醇激酶1抑制剂的设计和生物学评价

期刊:Breast Cancer Research and Treatment
影响因子:3
doi:10.1007/s10549-018-4900-1
Alshaker, Heba; Srivats, Shyam; Monteil, Danielle; Wang, Qi; Low, Caroline M R; Pchejetski, Dmitri
信号转导
发表日期：2018
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Combination of RAD001 (everolimus) and docetaxel reduces prostate and breast cancer cell VEGF production and tumour vascularisation independently of sphingosine-kinase-1

RAD001（依维莫司）与多西他赛的组合可减少前列腺和乳腺癌细胞 VEGF 的产生和肿瘤血管化，且不依赖于鞘氨醇激酶 1

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-017-03728-3
Heba Alshaker, Qi Wang, Torsten Böhler, Robert Mills, Mathias Winkler, Tawfiq Arafat, Yoshiaki Kawano, Dmitri Pchejetski
肿瘤
乳腺癌
肿瘤细胞
发表日期：2017
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