日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome bd Oxidase in Mycobacterium tuberculosis

一系列吡唑并喹唑啉胺类化合物抑制结核分枝杆菌中的细胞色素bd氧化酶

Singh, Samsher; Ng, Pearly Shuyi; Lakshmanan, Umayal; Mathiyazakan, Vikneswaran; Wiggins, Thomas; Lee, Bei Shi; Ang, Shi Hua; Lin Sim, Sandra Wei; Santos, May Delos; Moraski, Garrett; Miller, Marvin; Berney, Michael; Grüber, Gerhard; Pethe, Kevin

Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model

发现用于治疗恰加斯病的药物 IID432:一种氰基三唑类锥虫拓扑异构酶 II 抑制剂,在慢性感染模型中短期治疗后可实现完全治愈

René, Olivier; Saldivia, Manuel; Dauphinais, Maxime; Zhang, Lei; Hollingsworth, Scott A; Jiricek, Jan; Koester, Dennis C; Miller, Sarah L; Williams, Sarah L; Ng, Pearly S; Patra, Debjani; Jumani, Rajiv S; Baxley, Grace M; Osborne, Colin S; Chen, Ying-Bo; Chen, Yen-Liang; Cheung, Harry; Lakshminarayana, Suresh B; Galarneau, Jean-René; Diagana, Thierry T; Sarko, Christopher; Rao, Srinivasa P S

cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.

cGAS介导的I型干扰素信号传导促进药物难治性癫痫的疾病进展。

Huang Yige, Fan Li, Wong Man Ying, Lei Zhuofan, Krishnamachary Balaji, Zhu Daphne, Cadiz Mika, Nagiri Ravi Kumar, Ye Pearly, Norman Kendra, Bhagwat Maitreyee, Lee Young Jae, Li Hui, Zhu Jingjie, Amin Sadaf, Lauderdale Kelli, Chen Hao, Luo Wenjie, Gong Shiaoching, Liechty Benjamin L, Palop Jorge J, Sinha Subhash C, Wu Junfang, Zhao Mingrui, Gan Li

Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial

高危子宫内膜癌女性辅助放化疗与单纯放疗的比较(PORTEC-3):一项随机3期试验的10年临床结果及基于分子分型的事后分析

Post, Cathalijne C B; de Boer, Stephanie M; Powell, Melanie E; Mileshkin, Linda; Katsaros, Dionyssios; Bessette, Paul; Leary, Alexandra; Ottevanger, Petronella B; McCormack, Mary; Khaw, Pearly; D'Amico, Romerai; Fyles, Anthony; Chargari, Cyrus; Kitchener, Henry C; Do, Viet; Lissoni, Andrea; Provencher, Diane; Genestie, Catherine; Nijman, Hans W; Whitmarsh, Karen; Jürgenliemk-Schulz, Ina M; Feeney, Amanda; Lutgens, Ludy C H W; Bouma, Jeanette; Leon-Castillo, Alicia; Nout, Remi A; Putter, Hein; Bosse, Tjalling; Creutzberg, Carien L

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.

APOE3 基因中的 R136S 突变通过抑制 cGAS-STING-IFN 通路赋予机体抵抗 tau 病理的能力

Naguib Sarah, Lopez-Lee Chloe, Torres Eileen Ruth, Lee Se-In, Zhu Jingjie, Zhu Daphne, Ye Pearly, Norman Kendra, Zhao Mingrui, Wong Man Ying, Ambaw Yohannes A, Muñoz-Castañeda Rodrigo, Wang Wei, Patel Tark, Bhagwat Maitreyee, Norinsky Rada, Mok Sue-Ann, Walther Tobias C, Farese Robert V Jr, Luo Wenjie, Sinha Subhash C, Wu Zhuhao, Fan Li, Gong Shiaoching, Gan Li

STING-IFN-CH25H lipid axis links innate immune activation to tau pathology

STING-IFN-CH25H脂质轴将先天免疫激活与tau蛋白病理联系起来

Chen, Hao; Fan, Li; Wong, Man Ying; Ambaw, Yohannes A; Zhu, Jingjie; Norman, Kendra; Ye, Pearly; Foxe, Nessa; Zhu, Daphne; Wan, Yuansong; Srinivasan, Mahalashmi; Mok, Sue-Ann; McIntire, Laura Beth J; Walther, Tobias C; Farese, Robert V; Gan, Li; Luo, Wenjie

Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.

Tlr7 驱动与年龄和阿尔茨海默病相关的脱髓鞘的性别差异

Lopez-Lee Chloe, Kodama Lay, Fan Li, Zhu Daphne, Zhu Jingjie, Wong Man Ying, Ye Pearly, Norman Kendra, Foxe Nessa R, Ijaz Laraib, Yu Fangmin, Chen Hao, Carling Gillian K, Torres Eileen R, Kim Rachel D, Dubal Dena B, Liddelow Shane A, Sinha Subhash C, Luo Wenjie, Gan Li

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation

人类iPSC 4R tau蛋白病模型揭示了tau蛋白传播的调节因子

Celeste Parra Bravo ,Alice Maria Giani ,Jesus Madero-Perez ,Zeping Zhao ,Yuansong Wan ,Avi J Samelson ,Man Ying Wong ,Alessandro Evangelisti ,Ethan Cordes ,Li Fan ,Pearly Ye ,Daphne Zhu ,Tatyana Pozner ,Maria Mercedes ,Tark Patel ,Allan Yarahmady ,Gillian K Carling ,Fredrik H Sterky ,Virginia M Y Lee ,Edward B Lee ,Michael DeTure ,Dennis W Dickson ,Manu Sharma ,Sue-Ann Mok ,Wenjie Luo ,Mingrui Zhao ,Martin Kampmann ,Shiaoching Gong ,Li Gan

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.

阿尔茨海默病相关风险等位基因在 tau 蛋白病模型中加剧小胶质细胞 cGAS 相关的衰老和神经退行性变

Carling Gillian K, Fan Li, Foxe Nessa R, Norman Kendra, Wong Man Ying, Zhu Daphne, Corona Carlo, Razzoli Agnese, Yu Fangmin, Yarahmady Allan, Ye Pearly, Chen Hao, Huang Yige, Amin Sadaf, Sereda Rebecca, Lopez-Lee Chloe, Zacharioudakis Emmanouil, Chen Xiaoying, Xu Jielin, Cheng Feixiong, Gavathiotis Evripidis, Cuervo Ana Maria, Holtzman David M, Mok Sue-Ann, Sinha Subhash C, Sidoli Simone, Ratan Rajiv R, Luo Wenjie, Gong Shiaoching, Gan Li

APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition

APOE3-R136S 突变通过 cGAS-STING-IFN 抑制赋予对 tau 病理的抵抗力

Sarah Naguib, Eileen Ruth Torres, Chloe Lopez-Lee, Li Fan, Maitreyee Bhagwat, Kendra Norman, Se-In Lee, Jingjie Zhu, Pearly Ye, Man Ying Wong, Tark Patel, Sue-Ann Mok, Wenjie Luo, Subhash Sinha, Mingrui Zhao, Shiaoching Gong, Li Gan