日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules

利用特定因子对异源细胞进行部分重编程,以生成巨核细胞谱系限制性生物分子

Artuz, Crisbel M; Knights, Alexander J; Funnell, Alister P W; Gonda, Thomas J; Ravid, Katya; Pearson, Richard C M; Quinlan, Kate G R; Crossley, Merlin

Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch.

DNA结合因子之间的直接竞争凸显了Krüppel样因子1在红系/巨核系转换中的作用

Norton Laura J, Hallal Samantha, Stout Elizabeth S, Funnell Alister P W, Pearson Richard C M, Crossley Merlin, Quinlan Kate G R

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells

Krüppel样因子3对红系和非红系细胞中α-珠蛋白基因座的差异性调控

Funnell, Alister P W; Vernimmen, Douglas; Lim, Wooi F; Mak, Ka Sin; Wienert, Beeke; Martyn, Gabriella E; Artuz, Crisbel M; Burdach, Jon; Quinlan, Kate G R; Higgs, Douglas R; Whitelaw, Emma; Pearson, Richard C M; Crossley, Merlin

A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden

ONECUT结合位点中的CpG突变热点是B型血友病莱顿变异型的主要致病因素。

Funnell, Alister P W; Wilson, Michael D; Ballester, Benoit; Mak, Ka Sin; Burdach, Jon; Magan, Natisha; Pearson, Richard C M; Lemaigre, Frederic P; Stowell, Kathryn M; Odom, Duncan T; Flicek, Paul; Crossley, Merlin

Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing

构建同时缺乏KLF3/BKLF和KLF8的小鼠模型揭示了基因相互作用以及这些因子在胚胎珠蛋白基因沉默中的作用。

Funnell, Alister P W; Mak, Ka Sin; Twine, Natalie A; Pelka, Gregory J; Norton, Laura J; Radziewic, Tania; Power, Melinda; Wilkins, Marc R; Bell-Anderson, Kim S; Fraser, Stuart T; Perkins, Andrew C; Tam, Patrick P; Pearson, Richard C M; Crossley, Merlin

The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain

多锌指蛋白ZNF217通过其双指结构域与DNA相互作用。

Nunez, Noelia; Clifton, Molly M K; Funnell, Alister P W; Artuz, Crisbel; Hallal, Samantha; Quinlan, Kate G R; Font, Josep; Vandevenne, Marylène; Setiyaputra, Surya; Pearson, Richard C M; Mackay, Joel P; Crossley, Merlin

Cellular Reprogramming toward the Erythroid Lineage

向红系细胞重编程

Norton, Laura J; Funnell, Alister P W; Pearson, Richard C M; Crossley, Merlin

PU.1 and Haematopoietic Cell Fate: Dosage Matters

PU.1 与造血细胞命运:剂量至关重要

Mak, Ka Sin; Funnell, Alister P W; Pearson, Richard C M; Crossley, Merlin

Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis

靶向破坏基本 Krüppel 样因子基因 (Klf3) 揭示了其在脂肪生成中的作用

Sue, Nancy; Jack, Briony H A; Eaton, Sally A; Pearson, Richard C M; Funnell, Alister P W; Turner, Jeremy; Czolij, Robert; Denyer, Gareth; Bao, Shisan; Molero-Navajas, Juan Carlos; Perkins, Andrew; Fujiwara, Yuko; Orkin, Stuart H; Bell-Anderson, Kim; Crossley, Merlin