Peddy相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance.

在 Q175 亨廷顿病模型小鼠中抑制 mTOR 可促进神经元自噬和突变亨廷顿蛋白的清除

影响因子:6.4

doi:10.7554/eLife.104979

Stavrides Philip, Goulbourne Chris N, Peddy James, Huo Chunfeng, Rao Mala, Khetarpal Vinod, Marchionini Deanna M, Nixon Ralph A, Yang Dun-Sheng

发表日期：2025

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Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.

早期内体衔接蛋白 APPL1 的神经元表达增加，可重现阿尔茨海默病相关的内体和突触功能障碍以及胆碱能神经退行性变

期刊:Journal of Neuroscience

doi:10.1523/JNEUROSCI.2331-24.2025

Jiang Ying, Sachdeva Kuldeep, Goulbourne Chris N, Berg Martin J, Peddy James, Stavrides Philip H, Pensalfini Anna, Pawlik Monika, Malampati Sandeep, Whyte Lauren, Basavarajappa Balapal S, Subbanna Shivakumar, Bleiwas Cynthia, Smiley John F, Mathews Paul M, Nixon Ralph A

发表日期：2025

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Enhancing reading skills in at-risk students: the combined effects of smartphone format, cardiac coherence, positive feedback, and interest-based personalization

提高弱势学生的阅读能力：智能手机格式、心率一致性、积极反馈和基于兴趣的个性化教学的综合效果

期刊:Frontiers in Psychology

影响因子:2.9

doi:10.3389/fpsyg.2025.1602966

发表日期：2025

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mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

在Q175亨廷顿病模型小鼠中抑制mTOR可促进神经元自噬和突变亨廷顿蛋白的清除。

doi:10.1101/2024.05.29.596471

Stavrides, Philip; Goulbourne, Chris N; Peddy, James; Huo, Chunfeng; Rao, Mala; Khetarpal, Vinod; Marchionini, Deanna M; Nixon, Ralph A; Yang, Dun-Sheng

发表日期：2025

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Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration

早期内体衔接蛋白APPL1在神经元中的表达增加，会重现阿尔茨海默病相关的内体和突触功能障碍以及胆碱能神经退行性变。

doi:10.1101/2024.09.19.613736

Jiang, Ying; Sachdeva, Kuldeep; Goulbourne, Chris N; Berg, Martin J; Peddy, James; Stavrides, Philip H; Pensalfini, Anna; Pawlik, Monika; Malampati, Sandeep; Whyte, Lauren; Basavarajappa, Balapal S; Shivakumar, Subbanna; Bleiwas, Cynthia; Smiley, John F; Mathews, Paul M; Nixon, Ralph A

阿尔茨海默症

发表日期：2025

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Autophagy is a novel pathway for neurofilament protein degradation in vivo

自噬是体内神经丝蛋白降解的一种新途径

期刊:Autophagy

影响因子:14.6

doi:10.1080/15548627.2022.2124500

Mala V Rao, Sandipkumar Darji, Philip H Stavrides, Chris N Goulbourne, Asok Kumar, Dun-Sheng Yang, Lang Yoo, James Peddy, Ju-Hyun Lee, Aidong Yuan, Ralph A Nixon

细胞生物学

发表日期：2023

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Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

阿尔茨海默病小鼠模型中自噬溶酶体酸化异常会诱导神经元中Aβ的自噬性积累，从而形成老年斑。

期刊:Nature Neuroscience

影响因子:21.2

doi:10.1038/s41593-022-01084-8

Ju-Hyun Lee ，Dun-Sheng Yang ，Chris N Goulbourne ，Eunju Im ，Philip Stavrides ，Anna Pensalfini ，Han Chan ，Cedric Bouchet-Marquis ，Cynthia Bleiwas ，Martin J Berg ，Chunfeng Huo ，James Peddy ，Monika Pawlik ，Efrat Levy ，Mala Rao ，Mathias Staufenbiel ，Ralph A Nixon

阿尔茨海默症

发表日期：2022

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Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration

对 p38α 激酶抑制剂 neflamapimod 治疗基底前脑胆碱能变性的临床前和随机临床试验进行评估

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-022-32944-3

Ying Jiang # ,John J Alam # ,Stephen N Gomperts ,Paul Maruff ,Afina W Lemstra ,Ursula A Germann ,Philip H Stavrides ,Sandipkumar Darji ,Sandeep Malampati ,James Peddy ,Cynthia Bleiwas ,Monika Pawlik ,Anna Pensalfini ,Dun-Sheng Yang ,Shivakumar Subbanna ,Balapal S Basavarajappa ,John F Smiley ,Amanda Gardner ,Kelly Blackburn ,Hui-May Chu ,Niels D Prins ,Charlotte E Teunissen ,John E Harrison ,Philip Scheltens ,Ralph A Nixon

发表日期：2022

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Collagenase Clostridium Histolyticum-aaes for the Treatment of Cellulite in Women: Results From Two Phase 3 Randomized, Placebo-Controlled Trials

溶组织梭菌胶原酶治疗女性橘皮组织：两项3期随机、安慰剂对照试验的结果

期刊:Dermatologic Surgery

影响因子:2.2

doi:10.1097/DSS.0000000000002952

Kaufman-Janette, Joely; Joseph, John H; Kaminer, Michael S; Clark, James; Fabi, Sabrina G; Gold, Michael H; Goldman, Mitchel P; Katz, Bruce E; Peddy, Kappa; Schlessinger, Joel; Young, V Leroy; Davis, Matthew; Hurley, David; Liu, Genzhou; McLane, Michael P; Vijayan, Saji; Bass, Lawrence S

发表日期：2021

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Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease

直接过度激活 Rab5 引起的内体功能障碍重现了阿尔茨海默病的前驱症状和神经退行性特征

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2020.108420

Anna Pensalfini, Seonil Kim, Shivakumar Subbanna, Cynthia Bleiwas, Chris N Goulbourne, Philip H Stavrides, Ying Jiang, Ju-Hyun Lee, Sandipkumar Darji, Monika Pawlik, Chunfeng Huo, James Peddy, Martin J Berg, John F Smiley, Balapal S Basavarajappa, Ralph A Nixon

阿尔茨海默症

发表日期：2020

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