Peddy James相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance.

在 Q175 亨廷顿病模型小鼠中抑制 mTOR 可促进神经元自噬和突变亨廷顿蛋白的清除

影响因子:6.4

doi:10.7554/eLife.104979

Stavrides Philip, Goulbourne Chris N, Peddy James, Huo Chunfeng, Rao Mala, Khetarpal Vinod, Marchionini Deanna M, Nixon Ralph A, Yang Dun-Sheng

发表日期：2025

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Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.

早期内体衔接蛋白 APPL1 的神经元表达增加，可重现阿尔茨海默病相关的内体和突触功能障碍以及胆碱能神经退行性变

期刊:Journal of Neuroscience

doi:10.1523/JNEUROSCI.2331-24.2025

Jiang Ying, Sachdeva Kuldeep, Goulbourne Chris N, Berg Martin J, Peddy James, Stavrides Philip H, Pensalfini Anna, Pawlik Monika, Malampati Sandeep, Whyte Lauren, Basavarajappa Balapal S, Subbanna Shivakumar, Bleiwas Cynthia, Smiley John F, Mathews Paul M, Nixon Ralph A

发表日期：2025

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mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

在Q175亨廷顿病模型小鼠中抑制mTOR可促进神经元自噬和突变亨廷顿蛋白的清除。

doi:10.1101/2024.05.29.596471

Stavrides, Philip; Goulbourne, Chris N; Peddy, James; Huo, Chunfeng; Rao, Mala; Khetarpal, Vinod; Marchionini, Deanna M; Nixon, Ralph A; Yang, Dun-Sheng

发表日期：2025

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Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration

早期内体衔接蛋白APPL1在神经元中的表达增加，会重现阿尔茨海默病相关的内体和突触功能障碍以及胆碱能神经退行性变。

doi:10.1101/2024.09.19.613736

Jiang, Ying; Sachdeva, Kuldeep; Goulbourne, Chris N; Berg, Martin J; Peddy, James; Stavrides, Philip H; Pensalfini, Anna; Pawlik, Monika; Malampati, Sandeep; Whyte, Lauren; Basavarajappa, Balapal S; Shivakumar, Subbanna; Bleiwas, Cynthia; Smiley, John F; Mathews, Paul M; Nixon, Ralph A

阿尔茨海默症

发表日期：2025

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